Rheological insights into 3D printing of drug products: Drug nanocrystal-poloxamer gels for semisolid extrusion.

Autor: Junnila A; Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, § ,University of Helsinki, Helsinki, Finland. Electronic address: atte.junnila@helsinki.fi., Mortier L; Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, § ,University of Helsinki, Helsinki, Finland; Laboratory of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium., Arbiol A; Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, § ,University of Helsinki, Helsinki, Finland., Harju E; Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, § ,University of Helsinki, Helsinki, Finland., Tomberg T; Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, § ,University of Helsinki, Helsinki, Finland., Hirvonen J; Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, § ,University of Helsinki, Helsinki, Finland., Viitala T; Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, § ,University of Helsinki, Helsinki, Finland; Pharmaceutical Sciences Laboratory, Faculty of Science and Engineering, Åbo Akademi University, Turku, Finland., Karttunen AP; Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, § ,University of Helsinki, Helsinki, Finland., Peltonen L; Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, § ,University of Helsinki, Helsinki, Finland.
Jazyk: angličtina
Zdroj: International journal of pharmaceutics [Int J Pharm] 2024 Apr 25; Vol. 655, pp. 124070. Date of Electronic Publication: 2024 Mar 28.
DOI: 10.1016/j.ijpharm.2024.124070
Abstrakt: The importance of ink rheology to the outcome of 3D printing is well recognized. However, rheological properties of printing inks containing drug nanocrystals have not been widely investigated. Therefore, the objective of this study was to establish a correlation between the composition of nanocrystal printing ink, the ink rheology, and the entire printing process. Indomethacin was used as a model poorly soluble drug to produce nanosuspensions with improved solubility properties through particle size reduction. The nanosuspensions were further developed into semisolid extrusion 3D printing inks with varying nanocrystal and poloxamer 407 concentrations. Nanocrystals were found to affect the rheological properties of the printing inks both by being less self-supporting and having higher yielding resistances. During printing, nozzle blockages occurred. Nevertheless, all inks were found to be printable. Finally, the rheological properties of the inks were successfully correlated with various printing and product properties. Overall, these experiments shed new light on the rheological properties of printing inks containing nanocrystals.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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