Evaluation of the neuroprotective effect of quercetin against damage caused by gamma radiation.

Autor: Baran M; Department of Basic Sciences, Faculty of Pharmacy, Erciyes University, Kayseri, Turkey., Başaran KE; Department of Physiology, Faculty of Medicine, Erciyes University, Kayseri, Turkey., Gergin OO; Department of Anesthesiology and Reanimation, Faculty of Medicine, Erciyes University, Kayseri, Turkey., Cengız O; Department of Histology and Embryology, Faculty of Medicine, Erciyes University, Kayseri, Turkey., G Yıldız O; Department of Radiation Oncology, Faculty of Medicine, Erciyes University, Kayseri, Turkey., Yay A; Department of Histology and Embryology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.; Genome and Stem Cell Center (GENKOK), Erciyes University, Kayseri, Turkey.
Jazyk: angličtina
Zdroj: Journal of cancer research and therapeutics [J Cancer Res Ther] 2024 Jan 01; Vol. 20 (1), pp. 261-267. Date of Electronic Publication: 2023 Apr 06.
DOI: 10.4103/jcrt.jcrt_348_21
Abstrakt: Background and Objective: Radiation therapy is a routine clinical practice that has been used for a long time in the treatment of cancer patients. The most important dose-limiting organ in patients receiving radiotherapy for various conditions is the brain. The mechanisms underlying brain and pituitary gland damage caused by radiation are largely unknown. It is of great importance to use radioprotective agents to protect against damage. This study aims to evaluate the neuroprotective effects of quercetin in experimental radiation-induced brain and pituitary gland damage.
Materials and Methods: A total of 60 adult male Wistar-albino rats were randomly divided into six groups (control, sham, radiation, quercetin, radiation + quercetin, and quercetin + radiation groups, with ten rats in each group). Quercetin was given to rats by oral gavage at 50 mg/kg/day. A whole-body single dose of 10 Gy radiation was applied to the rats. Tissue samples belonging to the groups were compared after excision. Histopathological changes in the brain tissue and pituitary gland were examined with hematoxylin-tissue samples in the groups and compared histologically and immunohistochemically.
Results: The histopathological examination of the brain and anterior pituitary gland sections showed marked damage in the radiation-treated rats, while the quercetin-administered groups showed normal tissue architecture. While neuropeptid Y immunoreactivity was increased, synaptophysin immunoreactivity was decreased in the brains of radiation-treated rats. However, when neuropeptide Y and synaptophysin expression were assessed in the anterior pituitary gland, there was no significant difference between the groups.
Conclusion: Consequently, quercetin may be a potential pharmacological agent in modulating radiation-induced damage in rats. However, extra experimental and preclinical studies are needed to confirm our findings before they can be used clinically.
(Copyright © 2023 Copyright: © 2023 Journal of Cancer Research and Therapeutics.)
Databáze: MEDLINE
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