Design of cobalt-doped graphene quantum dot-decorated vanadium pentoxide nanosheet-based Off-On fluorescent sensor system for tiopronin sensing.

Autor: Nangare S; Department of Pharmaceutical Chemistry, H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur, MS, 425405, India., Kolte K; Department of Pharmaceutical Chemistry, H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur, MS, 425405, India., Khan Z; Department of Pharmaceutical Chemistry, H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur, MS, 425405, India., Patil A; Department of Pharmaceutical Chemistry, H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur, MS, 425405, India., Jadhav N; Department of Pharmaceutics, Krishna Institute of Pharmacy, Malkapur, Karad, MS, 415539, India., Boddu SHS; Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Ajman University, Ajman, UAE.; Center of Medical and Bio-Allied Health Sciences Research, Ajman University, P.O. Box 346, Ajman, UAE., Charde M; Government College of Pharmacy, Vidyanagar, Karad District, Satara, Maharashtra, 415124, India., Patil P; Department of Pharmaceutical Chemistry, H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur, MS, 425405, India. rxpatilpravin@yahoo.co.in.
Jazyk: angličtina
Zdroj: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry [Anal Sci] 2024 Jun; Vol. 40 (6), pp. 1177-1191. Date of Electronic Publication: 2024 Mar 30.
DOI: 10.1007/s44211-024-00548-0
Abstrakt: Despite the high medicinal value of tiopronin, there are substantial adverse effects such as yellow skin, yellow eyes, muscle aches, etc. Therefore, there is a huge necessity to identify tiopronin using advanced sensors in provided samples. Recently, the preference for graphene quantum dots (GQDs) and inorganic nanomaterial-based fluorescent sensors for the detection of pharmaceuticals has been extensively documented due to their plentiful advantages. Therefore, in this work, the cobalt-doped GQDs decorated vanadium pentoxide nanosheet-based fluorescence switch 'Off-On' sensor (Co-GQDs@V 2 O 5 -NS) was designed for highly sensitive and selective detection of tiopronin. Briefly, the green synthesis of highly fluorescent Co-GQDs was carried out using a hydrothermal method. Meanwhile, the synthesis of V 2 O 5 -NS was synthesized using the liquid exfoliation method. The synthesis of Co-GQDs@V 2 O 5 -NS was accomplished wherein Co-GQDs adsorbed on the surface of V 2 O 5 -NS that offered the quenching of fluorescence of Co-GQDs. Afterward, the addition of tiopronin into the quenched probe disclosed the proportional recovery of fluorescence of Co-GQDs. Here, the addition of tiopronin provides the decomposition of V 2 O 5 -NS and conversion into the V 4+ that aids in releasing the quenched fluorescence of Co-GQDs. The limit of detection and linearity range for tiopronin was found to be 1.43 ng/mL and 10-700 ng/mL, respectively. Moreover, it demonstrated high selectivity, good stability at experimental conditions, and practicality in analyzing tiopronin in spiked sample analysis. Hence, the designed Co-GQDs@V 2 O 5 -NS nanosized sensor enables high sensitivity, selectivity, simplicity, label-free, and eco-friendly tiopronin recognition. In the future, the utility of Co-GQDs@V 2 O 5 -NS can open a new door for sensing tiopronin in provided samples.
(© 2024. The Author(s), under exclusive licence to The Japan Society for Analytical Chemistry.)
Databáze: MEDLINE
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