Association of low hemoglobin at birth and neurodevelopmental outcomes in preterm neonates ≤28 weeks' gestation: a retrospective cohort study.

Autor: Elkhouli M; Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada.; Department of Pediatrics, Scarborough Health Network, Toronto, Ontario, Canada., Raghuram K; Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada.; Department of Pediatrics, Sinai Health System, Toronto, Ontario, Canada., Elhanafy T; Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada.; Department of Pediatrics, Sinai Health System, Toronto, Ontario, Canada., Asztalos E; Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada.; DAN Women & Babies Program, Sunnybrook Health Sciences Center, Toronto, Ontario, Canada., Banihani R; Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada.; DAN Women & Babies Program, Sunnybrook Health Sciences Center, Toronto, Ontario, Canada., Shah PS; Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada.; Department of Pediatrics, Sinai Health System, Toronto, Ontario, Canada., Mohamed A; Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada. Adel.mohamed@sinaihealth.ca.; Department of Pediatrics, Sinai Health System, Toronto, Ontario, Canada. Adel.mohamed@sinaihealth.ca.
Jazyk: angličtina
Zdroj: Journal of perinatology : official journal of the California Perinatal Association [J Perinatol] 2024 Jun; Vol. 44 (6), pp. 880-885. Date of Electronic Publication: 2024 Mar 29.
DOI: 10.1038/s41372-024-01946-y
Abstrakt: Objective: To compare neurodevelopmental outcomes at 18-24 months corrected age (CA) for preterm infants who had hemoglobin levels <120 g/l versus those with hemoglobin level ≥120 g/l at birth.
Methods: We included infants of ≤28 weeks gestational age (GA) born between January 2009 and June 2018. The primary outcome was neurodevelopmental impairment (NDI) at 18-24 months. Multivariable logistic regression was applied to determine the association.
Results: Of the 2351 eligible neonates, 351 (14.9%) had hemoglobin levels <120 g/L at birth. Of the 2113 surviving infants, 1534 (72.5%) underwent developmental follow-up at 18-24 months CA. There was no statistically significant difference in ND outcomes between the two groups. The composite outcome of death or NDI was significantly higher in the low hemoglobin group.
Conclusion: In preterm infants ≤28 weeks GA, initial hemoglobin <120 g/L at birth was not associated with neurodevelopmental impairment at 18-24 months CA among survivors.
(© 2024. Crown.)
Databáze: MEDLINE
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