Contemporary use of prophylactic probiotics in NICUs in the United States: a survey update.

Autor: Wala SJ; Center for Perinatal Research, Nationwide Children's Hospital, Columbus, OH, USA.; Department of Pediatric Surgery, Nationwide Children's Hospital, Columbus, OH, USA., Ragan MV; Center for Perinatal Research, Nationwide Children's Hospital, Columbus, OH, USA.; Department of Pediatric Surgery, Nationwide Children's Hospital, Columbus, OH, USA., Pryor E; NEC Society, Davis, CA, USA., Canvasser J; NEC Society, Davis, CA, USA., Diefenbach KA; Department of Pediatric Surgery, Nationwide Children's Hospital, Columbus, OH, USA., Besner GE; Center for Perinatal Research, Nationwide Children's Hospital, Columbus, OH, USA. gail.besner@nationwidechildrens.org.; Department of Pediatric Surgery, Nationwide Children's Hospital, Columbus, OH, USA. gail.besner@nationwidechildrens.org.
Jazyk: angličtina
Zdroj: Journal of perinatology : official journal of the California Perinatal Association [J Perinatol] 2024 May; Vol. 44 (5), pp. 739-744. Date of Electronic Publication: 2024 Mar 29.
DOI: 10.1038/s41372-024-01952-0
Abstrakt: Objective: In 2015, 14.0% of US NICUs administered probiotics to very low birth weight infants. Current probiotic use prior to and after the Fall of 2023 (when FDA warnings were issued) remains unknown.
Study Design: A survey was distributed to the American Academy of Pediatrics Section on Neonatal and Perinatal Medicine (August-November/2022) and Neonatology Solutions' Level III/IV NICUs (January-April/2023). Probiotic administration practices were investigated.
Results: In total, 289 unique NICUs and 406 providers responded to the survey. Of those, 29.1% of NICUs administered prophylactic probiotics to premature neonates, however, this decreased considerably after FDA warnings were issued. Additionally, 71.4% of providers stated willingness to administer probiotics to premature infants if there was an FDA-approved formulation.
Conclusions: Probiotic use in US NICUs increased between 2015 and the Fall of 2023 and then dropped dramatically following warning letters from the FDA. The introduction of an FDA-approved probiotic may further expand administration.
(© 2024. The Author(s).)
Databáze: MEDLINE
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