Standardization and preliminary characterization of an ayurvedic stress-relieving head massage oil of Nardostachys jatamansi DC.
| Autor: | Chavan Bhagwan S; Bharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Wagholi, Pune, 412 207, India; Atharva Nature Healthcare Pvt Ltd, Wagholi, Pune, 412 207, India. Electronic address: ictrcdrugresearch2016@gmail.com., Gupta VS; Bharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Wagholi, Pune, 412 207, India., Deshmukh VV; Bharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Wagholi, Pune, 412 207, India., Sardeshmukh SS; Bharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Wagholi, Pune, 412 207, India; Atharva Nature Healthcare Pvt Ltd, Wagholi, Pune, 412 207, India., Sardeshmukh SP; Bharatiya Sanskriti Darshan Trust's Integrated Cancer Treatment and Research Centre, Wagholi, Pune, 412 207, India; Atharva Nature Healthcare Pvt Ltd, Wagholi, Pune, 412 207, India. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Journal of Ayurveda and integrative medicine [J Ayurveda Integr Med] 2024 Mar-Apr; Vol. 15 (2), pp. 100900. Date of Electronic Publication: 2024 Mar 28. |
| DOI: | 10.1016/j.jaim.2024.100900 |
| Abstrakt: | Background: Jatamansi/Nardostachys jatamansi (NJ) is an important aromatic shrub widely used by Ayurvedic practitioners for centuries due to its usefulness in intellect-enhancing (Medhya), strengthening (Balya), and skin disorders. Several classical dosage forms like hot or cold infusion, decoction, distillate, powders, etc. have been mentioned for NJ. Clinical trials of Jatamansi Oil (JO) as a head massage conducted by clinicians and therapists have shown encouraging results in de-stressing/stress management of cancer patients through head anointing treatment. Objective: Such effective proprietary formulation needs assessment of its characteristics using modern analytical technologies to comprehend the Ayurvedic concept of dermal pharmacology. Materials and Methods: Triplicate batches of JO were prepared by evaporating its decoction in sesame oil (SO). Basic physicochemical analysis of the raw material, in-process samples, and finished products was carried out to develop a monograph. Further, raw SO and finished product JO were subjected to TLC, and extracted in hexane and dichloromethane separately for Gas Chromatography-Mass Spectrometry (GC-MS) analysis to profile several bioactive molecules from NJ in the final product, JO. Results: Standard Operating Procedure was developed and a basic monograph was prepared for JO. GC-MS analysis revealed several phytocompounds dissolved/dispersed in SO after processing, while 18 additional distinct peaks were observed in JO as compared to SO. Conclusion: This preliminary analysis supports the Ayurvedic concept of lipid-based formulations. The plausible phytocompounds anticipated based on retention times can be further quantified and studied for their probable action as anointing treatment. A detailed experimental strategy for understanding the phytochemical changes during the entire process needs to be planned and performed. Competing Interests: Declaration of competing interest JO has been partly included in a patent application, “A Herbo-Mineral Metallic Pharmaceutical Kit” application no. 202121011657 for an Indian patent and published as well as in PCT application no. PCT/IB2022/052192 and US Patent application no. 18/281,545 for Triple Negative Breast Cancer patients. (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|