Fungal footprints in oral cancer: unveiling the oral mycobiome.

Autor:	Monteiro JS; Department of Oral and Maxillofacial Surgery, Manipal College of Dental Sciences Mangalore, Manipal Academy of Higher Education, Manipal, India., Kaushik K; Department of Oral and Maxillofacial Surgery, Manipal College of Dental Sciences, Mangalore, India., de Arruda JAA; Department of Oral Diagnosis and Pathology, School of Dentistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil., Georgakopoulou E; Laboratory of Histology-Embryology, Molecular Carcinogenesis Group, Medical School, National and Kapodistrian University of Athens, Athens, Greece., Vieira AT; Laboratory of Microbiota and Immunomodulation, Department of Biochemistry and Immunology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Silva TA; Department of Oral Surgery, Pathology and Clinical Dentistry, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Devadiga D; Department of Conservative Dentistry and Endodontics, AB Shetty Memorial Institute of Dental Sciences, NITTE (Deemed to be University), Mangalore, India., Anyanechi CE; Department of Oral and Maxillofacial Surgery, University of Calabar/University of Calabar Teaching Hospital, Calabar, Nigeria., Shetty S; Department of Oral and Maxillofacial Surgery, Manipal College of Dental Sciences, Mangalore, India.
Jazyk:	angličtina
Zdroj:	Frontiers in oral health [Front Oral Health] 2024 Mar 14; Vol. 5, pp. 1360340. Date of Electronic Publication: 2024 Mar 14 (Print Publication: 2024).
DOI:	10.3389/froh.2024.1360340
Abstrakt:	Oral squamous cell carcinoma (OSCC) is the most common type of head and neck cancer, with a high mortality rate. There is growing evidence supporting a link between oral cancer and the microbiome. The microbiome can impact various aspects of cancer, such as pathogenesis, diagnosis, treatment, and prognosis. While there is existing information on bacteria and its connection to oral cancer, the fungi residing in the oral cavity represent a significant component of the microbiome that remains in its early stages of exploration and understanding. Fungi comprise a minuscule part of the human microbiome called the mycobiome. Mycobiome is ubiquitous in the human body but a weakened immune system offers a leeway space for fungi to showcase its virulence. The role of mycobiome as a colonizer, facilitator, or driver of carcinogenesis is still ambiguous. Reactivating the mycobiome that undergoes collateral damage associated with cancer treatment can be watershed event in cancer research. The coordinated, virulent, non-virulent behavior of the fungi once they reach a critical density must be hacked, considering its diagnostic, prognostic and therapeutic implications in cancer. This review highlights the diversity of the mycobiome and its potential role in oral cancer. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. (© 2024 Monteiro, Kaushik, de Arruda, Georgakopoulou, Vieira, Silva, Devadiga, Anyanechi and Shetty.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu