Proposed novel classification of circumscribed Lower-Grade Gliomas (cLGG) vs. infiltrating Lower-Grade Gliomas (iLGG): Correlations of radiological features and clinical outcomes.

Autor: Khan AA; Department of Surgery, Aga Khan University, Karachi, Pakistan., Khalid MU; Department of Surgery, Aga Khan University, Karachi, Pakistan., Bajwa MH; Department of Surgery, Aga Khan University, Karachi, Pakistan., Urooj F; Department of Surgery, Aga Khan University, Karachi, Pakistan., Tahir I; Medical College, Aga Khan University, Karachi, Pakistan., Angez M; Medical College, Aga Khan University, Karachi, Pakistan., Zahid F; Department of Surgery, Aga Khan University, Karachi, Pakistan., Saeed Baqai MW; Department of Surgery, Aga Khan University, Karachi, Pakistan., Aftab K; Department of Surgery, Aga Khan University, Karachi, Pakistan., Ansari S; Department of Computer Science, GIK Institute of Engineering Sciences and Technology, KPK, Pakistan., Khan UW; Department of Surgery, Aga Khan University, Karachi, Pakistan., Ahmed AA; Medical College, Aga Khan University, Karachi, Pakistan., Enam SA; Department of Surgery, Aga Khan University, Karachi, Pakistan.
Jazyk: angličtina
Zdroj: World neurosurgery: X [World Neurosurg X] 2024 Mar 01; Vol. 23, pp. 100356. Date of Electronic Publication: 2024 Mar 01 (Print Publication: 2024).
DOI: 10.1016/j.wnsx.2024.100356
Abstrakt: Purpose: We hypothesize that lower grade gliomas (LGG) can be identified and classified into two distinct subtypes: radiologically circumscribed Lower-Grade Gliomas (cLGG) and infiltrating Lower-Grade Gliomas (iLGG) based on radiological parameters and that these two different subtypes behave differently in terms of clinical outcomes.
Methods: We conducted a retrospective cohort study on surgical patients diagnosed with lower grade glioma over five years. Patient records and MRIs were reviewed, and neurosurgeons classified tumors into cLGG and iLGG groups.
Results: From the 165 patients in our cohort, 30 (18.2%) patients were classified as cLGG and 135 (81.8%) patients were classified as iLGG Mean age in cLGG was 31.4 years while mean age in iLGG was 37.9 years ( p  = 0.004). There was significant difference in mean blood loss between cLGG and iLGG groups (270 and 411 ml respectively, p  = 0.020). cLGG had a significantly higher proportion of grade II tumors ( p  < 0.001). The overall mean survival time for the iLGG group was 14.96 ± 1.23 months, and 18.77 ± 2.72 months for the cLGG group. In univariate cox regression, the survival difference between LGG groups was not significant (HR = 0.888, p  = 0.581), however on multivariate regression cLGG showed a significant (aHZ = 0.443, p  = 0.015) positive correlation with survival. Intense contrast enhancement (HZ = 41.468, p  = 0.018), blood loss (HZ = 1.002, p  = 0.049), and moderately high Ki-67 (HZ = 4.589, p  = 0.032) were also significant on univariate analyses.Conclusion: cLGG and iLGG are radiologically distinct groups with separate prognoses, surgical experience, and associations.
Competing Interests: The authors have no relevant financial or non-financial interests to disclose.
(© 2024 Published by Elsevier Inc.)
Databáze: MEDLINE
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