Recent advances in photodynamic therapy combined with chemotherapy for cervical cancer: a systematic review.

Autor:	Carobeli LR; Department of Clinical Analysis and Biomedicine, State University of Maringá, Maringá, Paraná, Brazil.; Graduate Program in Biosciences and Physiopathology, State University of Maringá, Maringá, Paraná, Brazil., Santos ABC; Department of Clinical Analysis and Biomedicine, State University of Maringá, Maringá, Paraná, Brazil.; Graduate Program in Biosciences and Physiopathology, State University of Maringá, Maringá, Paraná, Brazil., Martins LBM; Department of Clinical Analysis and Biomedicine, State University of Maringá, Maringá, Paraná, Brazil., Damke E; Department of Clinical Analysis and Biomedicine, State University of Maringá, Maringá, Paraná, Brazil., Consolaro MEL; Department of Clinical Analysis and Biomedicine, State University of Maringá, Maringá, Paraná, Brazil.; Graduate Program in Biosciences and Physiopathology, State University of Maringá, Maringá, Paraná, Brazil.
Jazyk:	angličtina
Zdroj:	Expert review of anticancer therapy [Expert Rev Anticancer Ther] 2024 May; Vol. 24 (5), pp. 263-282. Date of Electronic Publication: 2024 Apr 02.
DOI:	10.1080/14737140.2024.2337259
Abstrakt:	Introduction: Despite the evidence that photodynamic therapy (PDT) associated with chemotherapy presents great potential to overcome the limitations of monotherapy, little is known about the current status of this combination against cervical cancer. This systematic review aimed to address the currently available advances in combining PDT and chemotherapy in different research models and clinical trials of cervical cancer. Methods: We conducted a systematic review based on PRISMA Statement and Open Science Framework review protocol using PubMed, Web of Science, Embase, Scopus, LILACS, and Cochrane databases. We selected original articles focusing on 'Uterine Cervical Neoplasms' and 'Photochemotherapy and Chemotherapy' published in the last 10 years. The risk of bias in the studies was assessed using the CONSORT and SYRCLE tools. Results: Twenty-three original articles were included, focusing on HeLa cells, derived from endocervical adenocarcinoma and on combinations of several chemotherapeutics. Most of the combinations used modern drug delivery systems for improved simultaneous delivery and presented promising results with increased cytotoxicity compared to monotherapy. Conclusion: Despite the scarcity of animal studies and the absence of clinical studies, the combination of chemotherapy with PDT presents a potential option for cervical cancer therapy requiring additional studies. Osf Registration: https://doi.org/10.17605/OSF.IO/WPHN5 [Figure: see text].
Databáze:	MEDLINE
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