Outcomes of COVID-19 re-infections: a single-center cohort of 167 patients with systemic rheumatic diseases.

Autor: Panagiotopoulos A; Department of Propaedeutic Internal Medicine, School of Medicine, Joint Academic Rheumatology Program, National and Kapodistrian University of Athens, Mikras Asias 75 Str, Athens, Greece., Fragoulis GE; Department of Propaedeutic Internal Medicine, School of Medicine, Joint Academic Rheumatology Program, National and Kapodistrian University of Athens, Mikras Asias 75 Str, Athens, Greece. geofragoul@yahoo.gr., Arida A; Department of Propaedeutic Internal Medicine, School of Medicine, Joint Academic Rheumatology Program, National and Kapodistrian University of Athens, Mikras Asias 75 Str, Athens, Greece., Bournia VK; Department of Propaedeutic Internal Medicine, School of Medicine, Joint Academic Rheumatology Program, National and Kapodistrian University of Athens, Mikras Asias 75 Str, Athens, Greece., Evangelatos G; Department of Propaedeutic Internal Medicine, School of Medicine, Joint Academic Rheumatology Program, National and Kapodistrian University of Athens, Mikras Asias 75 Str, Athens, Greece., Fragkiadaki K; Department of Propaedeutic Internal Medicine, School of Medicine, Joint Academic Rheumatology Program, National and Kapodistrian University of Athens, Mikras Asias 75 Str, Athens, Greece., Kravvariti E; Department of Propaedeutic Internal Medicine, School of Medicine, Joint Academic Rheumatology Program, National and Kapodistrian University of Athens, Mikras Asias 75 Str, Athens, Greece., Laskari K; Department of Propaedeutic Internal Medicine, School of Medicine, Joint Academic Rheumatology Program, National and Kapodistrian University of Athens, Mikras Asias 75 Str, Athens, Greece., Mylona M; Department of Propaedeutic Internal Medicine, School of Medicine, Joint Academic Rheumatology Program, National and Kapodistrian University of Athens, Mikras Asias 75 Str, Athens, Greece., Michalakeas N; Department of Propaedeutic Internal Medicine, School of Medicine, Joint Academic Rheumatology Program, National and Kapodistrian University of Athens, Mikras Asias 75 Str, Athens, Greece., Papazoglou N; Department of Propaedeutic Internal Medicine, School of Medicine, Joint Academic Rheumatology Program, National and Kapodistrian University of Athens, Mikras Asias 75 Str, Athens, Greece., Pappa M; Department of Propaedeutic Internal Medicine, School of Medicine, Joint Academic Rheumatology Program, National and Kapodistrian University of Athens, Mikras Asias 75 Str, Athens, Greece., Poulia V; Department of Propaedeutic Internal Medicine, School of Medicine, Joint Academic Rheumatology Program, National and Kapodistrian University of Athens, Mikras Asias 75 Str, Athens, Greece., Panopoulos S; Department of Propaedeutic Internal Medicine, School of Medicine, Joint Academic Rheumatology Program, National and Kapodistrian University of Athens, Mikras Asias 75 Str, Athens, Greece., Ziarangali S; Department of Propaedeutic Internal Medicine, School of Medicine, Joint Academic Rheumatology Program, National and Kapodistrian University of Athens, Mikras Asias 75 Str, Athens, Greece., Papatheodorou V; Department of Propaedeutic Internal Medicine, School of Medicine, Joint Academic Rheumatology Program, National and Kapodistrian University of Athens, Mikras Asias 75 Str, Athens, Greece., Tektonidou MG; Department of Propaedeutic Internal Medicine, School of Medicine, Joint Academic Rheumatology Program, National and Kapodistrian University of Athens, Mikras Asias 75 Str, Athens, Greece., Sfikakis PP; Department of Propaedeutic Internal Medicine, School of Medicine, Joint Academic Rheumatology Program, National and Kapodistrian University of Athens, Mikras Asias 75 Str, Athens, Greece.
Jazyk: angličtina
Zdroj: Rheumatology international [Rheumatol Int] 2024 Sep; Vol. 44 (9), pp. 1733-1737. Date of Electronic Publication: 2024 Mar 29.
DOI: 10.1007/s00296-024-05573-w
Abstrakt: Data on COVID-19 re-infections in patients with systemic rheumatic diseases (SRDs) are lacking. We aimed to describe the course and outcomes of COVID-19 re-infections in these patients versus controls. In this single-center retrospective study, we included 167 consecutive SRD patients with at least one COVID-19 re-infection (mean age 47.3 years, females 70.7%). SRD patients were compared in terms of patient-perceived COVID-19 re-infection severity and hospitalizations/deaths with 167 age/sex-matched non-SRD controls. Logistic regression analysis was performed to assess potential milder re-infection versus primary infection severity, adjusting for study group, demographics (age, sex), vaccination status, body mass index, smoking, and comorbidities. 23 and 7 out of 167 re-infected SRD patients experienced two and three re-infections, respectively, which were comparable to the re-infection rates in controls (two: 32; and three: 2) who also had comparable COVID-19 vaccination history (89% and 95% vaccinated, respectively). In the initial infection, patients with SRDs were hospitalized (7.2% versus 1.8%, p = 0.017), and had received antiviral treatment (16.1% versus 4.7%, p < 0.001) more frequently than controls. However, hospitalizations (1.8% vs 0.6%) and antiviral treatment (7.8% vs 3.5%) did not differ (p > 0.05) between patients and controls at the first re-infection, as well as during the second and third re-infection; no deaths were recorded. Perceived severity of re-infections was also comparable between patients and controls (p = 0.847) and among those on biologic DMARDs or not (p = 0.482). In multivariable analysis, neither SRDs presence nor demographics or comorbidities were associated with COVID-19 re-infection severity. COVID-19 re-infection severity (patient-perceived/hospitalizations/deaths) did not differ between SRDs and controls.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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