Increased oxidative stress in shoe industry workers with low-level exposure to a mixture of volatile organic compounds.

Autor: Umićević N; University of Banja Luka Faculty of Medicine, Department of Toxicology, Banja Luka, Bosnia and Herzegovina.; University of Belgrade Faculty of Pharmacy, Department of Toxicology 'Akademik Danilo Soldatović', Belgrade, Serbia., Kotur-Stevuljević J; University of Belgrade Faculty of Pharmacy, Department of Medical Biochemistry, Belgrade, Serbia., Baralić K; University of Belgrade Faculty of Pharmacy, Department of Toxicology 'Akademik Danilo Soldatović', Belgrade, Serbia., Đukić-Ćosić D; University of Banja Luka Faculty of Medicine, Department of Toxicology, Banja Luka, Bosnia and Herzegovina.; University of Belgrade Faculty of Pharmacy, Department of Toxicology 'Akademik Danilo Soldatović', Belgrade, Serbia., Miljaković EA; University of Belgrade Faculty of Pharmacy, Department of Toxicology 'Akademik Danilo Soldatović', Belgrade, Serbia., Đorđević AB; University of Belgrade Faculty of Pharmacy, Department of Toxicology 'Akademik Danilo Soldatović', Belgrade, Serbia., Ćurčić M; University of Belgrade Faculty of Pharmacy, Department of Toxicology 'Akademik Danilo Soldatović', Belgrade, Serbia., Bulat Z; University of Belgrade Faculty of Pharmacy, Department of Toxicology 'Akademik Danilo Soldatović', Belgrade, Serbia., Antonijević B; University of Banja Luka Faculty of Medicine, Department of Toxicology, Banja Luka, Bosnia and Herzegovina.; University of Belgrade Faculty of Pharmacy, Department of Toxicology 'Akademik Danilo Soldatović', Belgrade, Serbia.
Jazyk: angličtina
Zdroj: Arhiv za higijenu rada i toksikologiju [Arh Hig Rada Toksikol] 2024 Mar 29; Vol. 75 (1), pp. 51-60. Date of Electronic Publication: 2024 Mar 29 (Print Publication: 2024).
DOI: 10.2478/aiht-2024-75-3804
Abstrakt: This study aimed to assess the redox status and trace metal levels in 49 shoe industry workers (11 men and 38 women) occupationally exposed to a mixture of volatile organic compounds (VOCs), which includes aliphatic hydrocarbons, aromatic hydrocarbons, ketones, esters, ethers, and carboxylic acids. All measured VOCs were below the permitted occupational exposure limits. The control group included 50 unexposed participants (25 men and 25 women). The following plasma parameters were analysed: superoxide anion (O 2 •- ), advanced oxidation protein products (AOPP), total oxidative status (TOS), prooxidant-antioxidant balance (PAB), oxidative stress index (OSI), superoxide dismutase (SOD) and paraoxonase-1 (PON1) enzyme activity, total SH group content (SHG), and total antioxidant status (TAS). Trace metal levels (copper, zinc, iron, magnesium, and manganese) were analysed in whole blood. All oxidative stress and antioxidative defence parameters were higher in the exposed workers than controls, except for PON1 activity. Higher Fe, Mg, and Zn, and lower Cu were observed in the exposed vs control men, while the exposed women had higher Fe and lower Mg, Zn, and Cu than their controls. Our findings confirm that combined exposure to a mixture of VOCs, even at permitted levels, may result in additive or synergistic adverse health effects and related disorders. This raises concern about current risk assessments, which mainly rely on the effects of individual chemicals, and calls for risk assessment approaches that can explain combined exposure to multiple chemicals.
(© 2024 Nina Umićević et al., published by Sciendo.)
Databáze: MEDLINE
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