Functional Recovery Associated with Dendrite Regeneration in PVD Neuron of Caenorhabditis elegans .

Autor:	Brar HK; Department of Cellular and Molecular Neuroscience, National Brain Research Centre, Manesar 122052, Haryana, India., Dey S; Department of Cellular and Molecular Neuroscience, National Brain Research Centre, Manesar 122052, Haryana, India., Singh P; Department of Cellular and Molecular Neuroscience, National Brain Research Centre, Manesar 122052, Haryana, India., Pande D; Department of Cellular and Molecular Neuroscience, National Brain Research Centre, Manesar 122052, Haryana, India., Ghosh-Roy A; Department of Cellular and Molecular Neuroscience, National Brain Research Centre, Manesar 122052, Haryana, India anindya@nbrc.ac.in.
Jazyk:	angličtina
Zdroj:	ENeuro [eNeuro] 2024 May 21; Vol. 11 (5). Date of Electronic Publication: 2024 May 21 (Print Publication: 2024).
DOI:	10.1523/ENEURO.0292-23.2024
Abstrakt:	PVD neuron of Caenorhabditis elegans is a highly polarized cell with well-defined axonal, and dendritic compartments. PVD neuron operates in multiple sensory modalities including the control of both nociceptive touch sensation and body posture. Although both the axon and dendrites of this neuron show a regeneration response following laser-assisted injury, it is rather unclear how the behavior associated with this neuron is affected by the loss of these structures. It is also unclear whether neurite regrowth would lead to functional restoration in these neurons. Upon axotomy, using a femtosecond laser, we saw that harsh touch response was specifically affected leaving the body posture unperturbed. Subsequently, recovery in the touch response is highly correlated to the axon regrowth, which was dependent on DLK-1/MLK-1 MAP Kinase. Dendrotomy of both major and minor primary dendrites affected the wavelength and amplitude of sinusoidal movement without any apparent effect on harsh touch response. We further correlated the recovery in posture behavior to the type of dendrite regeneration events. We found that dendrite regeneration through the fusion and reconnection between the proximal and distal branches of the injured dendrite corresponded to improved recovery in posture. Our data revealed that the axons and dendrites of PVD neurons regulate the nociception and proprioception in worms, respectively. It also revealed that dendrite and axon regeneration lead to the restoration of these differential sensory modalities. Competing Interests: The authors declare no competing financial interests. (Copyright © 2024 Brar et al.)
Databáze:	MEDLINE
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