Increases in functional connectivity between the default mode network and sensorimotor network correlate with symptomatic improvement after transcranial direct current stimulation for obsessive-compulsive disorder.

Autor: Echevarria MAN; LIM-23, Department of Psychiatry, Faculdade de Medicina, Universidade de São Paulo, SP, Brazil. Electronic address: marcoechevarria@usp.br., Batistuzzo MC; LIM-23, Department of Psychiatry, Faculdade de Medicina, Universidade de São Paulo, SP, Brazil; Department of Methods and Techniques in Psychology, Pontifical Catholic University, São Paulo, SP, Brazil., Silva RMF; LIM-23, Department of Psychiatry, Faculdade de Medicina, Universidade de São Paulo, SP, Brazil., Brunoni AR; LIM-23, Department of Psychiatry, Faculdade de Medicina, Universidade de São Paulo, SP, Brazil., Sato JR; Center of Mathematics, Computing and Cognition, Universidade Federal do ABC, SP, Brazil., Miguel EC; LIM-23, Department of Psychiatry, Faculdade de Medicina, Universidade de São Paulo, SP, Brazil., Hoexter MQ; LIM-23, Department of Psychiatry, Faculdade de Medicina, Universidade de São Paulo, SP, Brazil., Shavitt RG; LIM-23, Department of Psychiatry, Faculdade de Medicina, Universidade de São Paulo, SP, Brazil.
Jazyk: angličtina
Zdroj: Journal of affective disorders [J Affect Disord] 2024 Jun 15; Vol. 355, pp. 175-183. Date of Electronic Publication: 2024 Mar 26.
DOI: 10.1016/j.jad.2024.03.141
Abstrakt: Background: Non-invasive neuromodulation is a promising intervention for obsessive-compulsive disorder (OCD), although its neurobiological mechanisms of action are still poorly understood. Recent evidence suggests that abnormalities in the connectivity of the default mode network (DMN) and the supplementary motor area (SMA) with other brain regions and networks are involved in OCD pathophysiology. We examined if transcranial direct current stimulation (tDCS) alters these connectivity patterns and if they correlate with symptom improvement in treatment-resistant OCD.
Methods: In 23 patients from a larger clinical trial (comparing active tDCS to sham) who underwent pre- and post-treatment MRI scans, we assessed resting-state functional MRI (rs-fMRI) data. The treatment involved 30-minute daily tDCS sessions for four weeks (weekdays only), with the cathode over the SMA and the anode over the left deltoid. We conducted whole-brain connectivity analysis comparing active tDCS-treated to sham-treated patients.
Results: We found that active tDCS, but not sham, led to connectivity increasing between the DMN and the bilateral pre/postcentral gyri (p = 0.004, FDR corrected) and temporal-auditory areas plus the SMA (p = 0.028, FDR corrected). Also, symptom improvement was directly associated with connectivity increasing between the left lateral sensorimotor network and the left precuneus (r = 0.589, p = 0.034).
Limitations: Limited sample size (23 participants with resting-state neuroimaging), inability to analyze specific OCD symptom dimensions (e.g., harm, sexual/religious, symmetry/checking, cleaning/contamination).
Conclusions: These data offer novel information concerning functional connectivity changes associated with non-invasive neuromodulation interventions in OCD and can guide new brain stimulation interventions in the framework of personalized interventions.
Competing Interests: Declaration of competing interest All authors declare no competing interests.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE