Neurocognition and brain functional connectivity in a non-clinical population-based sample with psychotic experiences.

Autor: Ragazzi TCC; Department of Neuroscience and Behaviour, Ribeirão Preto Medical School, University of São Paulo, Brazil, 3900, Bandeirantes Avenue, Monte Alegre, 14040-900 Ribeirão Preto, São Paulo, Brazil. Electronic address: taciana.ragazzi@gmail.com., Shuhama R; Department of Neuroscience and Behaviour, Ribeirão Preto Medical School, University of São Paulo, Brazil, 3900, Bandeirantes Avenue, Monte Alegre, 14040-900 Ribeirão Preto, São Paulo, Brazil. Electronic address: rshuhama@hcrp.usp.br., da Silva PHR; Department of Physics, InBrain Laboratory, Faculty of Philosophy Sciences and Letters of Ribeirão Preto-University of Sao Paulo, Brazil, 3900, Bandeirantes Avenue, Monte Alegre, 14040-901 Ribeirão Preto, São Paulo, Brazil. Electronic address: pedrojoanabrit@usp.br., Corsi-Zuelli F; Department of Neuroscience and Behaviour, Ribeirão Preto Medical School, University of São Paulo, Brazil, 3900, Bandeirantes Avenue, Monte Alegre, 14040-900 Ribeirão Preto, São Paulo, Brazil. Electronic address: fabiana.zuelli@usp.br., Loureiro CM; Department of Neuroscience and Behaviour, Ribeirão Preto Medical School, University of São Paulo, Brazil, 3900, Bandeirantes Avenue, Monte Alegre, 14040-900 Ribeirão Preto, São Paulo, Brazil. Electronic address: camila.loureiro@usp.br., da Roza DL; Department of Neuroscience and Behaviour, Ribeirão Preto Medical School, University of São Paulo, Brazil, 3900, Bandeirantes Avenue, Monte Alegre, 14040-900 Ribeirão Preto, São Paulo, Brazil; Department of Epidemiology, School of Public Health, University of São Paulo, São Paulo, SP, Brazil. Electronic address: daianeroza@usp.br., Leoni RF; Department of Physics, InBrain Laboratory, Faculty of Philosophy Sciences and Letters of Ribeirão Preto-University of Sao Paulo, Brazil, 3900, Bandeirantes Avenue, Monte Alegre, 14040-901 Ribeirão Preto, São Paulo, Brazil. Electronic address: leonirf@usp.br., Menezes PR; Department of Preventive Medicine, Faculty of Medicine, University of São Paulo, Brazil, Population Mental Health Research Centre, Brazil, 455, Dr. Arnaldo Avenue, Cerqueira César, 01246903 São Paulo, São Paulo, Brazil. Electronic address: pmenezes@usp.br., Del-Ben CM; Department of Neuroscience and Behaviour, Ribeirão Preto Medical School, University of São Paulo, Brazil, 3900, Bandeirantes Avenue, Monte Alegre, 14040-900 Ribeirão Preto, São Paulo, Brazil. Electronic address: delben@fmrp.usp.br.
Jazyk: angličtina
Zdroj: Schizophrenia research [Schizophr Res] 2024 May; Vol. 267, pp. 156-164. Date of Electronic Publication: 2024 Mar 27.
DOI: 10.1016/j.schres.2024.03.026
Abstrakt: We characterized the neurocognitive profile of communed-based individuals and unaffected siblings of patients with psychosis from Brazil reporting psychotic experiences (PEs). We also analyzed associations between PEs and the intra and inter-functional connectivity (FC) in the Default Mode Network (DMN), the Fronto-Parietal Network (FPN) and the Salience Network (SN) measured by functional magnetic resonance imaging. The combined sample of communed-based individuals and unaffected siblings of patients with psychosis comprised 417 (neurocognition) and 85 (FC) volunteers who were divided as having low (<75th percentile) and high (≥75th percentile) PEs (positive, negative, and depressive dimensions) assessed by the Community Assessment of Psychic Experiences. The neurocognitive profile and the estimated current brief intellectual quotient (IQ) were assessed using the digit symbol (processing speed), arithmetic (working memory), block design (visual learning) and information (verbal learning) subtests of Wechsler Adult Intelligence Scale-third edition. Logistic regression models were performed for neurocognitive analysis. For neuroimaging, we used the CONN toolbox to assess FC between the specified regions, and ROI-to-ROI analysis. In the combined sample, high PEs (all dimensions) were related to lower processing speed performance. High negative PEs were related to poor visual learning performance and lower IQ, while high depressive PEs were associated with poor working memory performance. Those with high negative PEs presented FPN hypoconnectivity between the right and left lateral prefrontal cortex. There were no associations between PEs and the DMN and SN FC. Brazilian individuals with high PEs showed neurocognitive impairments like those living in wealthier countries. Hypoconnectivity in the FPN in a community sample with high PEs is coherent with the hypothesis of functional dysconnectivity in schizophrenia.
Competing Interests: Declaration of competing interest None.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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