Neural correlates of increased alcohol demand following alcohol cue exposure in adult heavy drinkers.

Autor: Amlung M; Cofrin Logan Center for Addiction Research and Treatment, University of Kansas, Lawrence, KS, USA; Department of Applied Behavioral Science, University of Kansas, Lawrence, KS, USA. Electronic address: mamlung@ku.edu., Marsden E; Peter Boris Centre for Addictions Research, McMaster University, Hamilton, ON, Canada., Hargreaves T; Peter Boris Centre for Addictions Research, McMaster University, Hamilton, ON, Canada., Sweet LH; Department of Psychology, University of Memphis, Memphis, TN, USA., Murphy JG; Department of Psychology, University of Georgia, Athens, GA, USA., MacKillop J; Peter Boris Centre for Addictions Research, McMaster University, Hamilton, ON, Canada; Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.
Jazyk: angličtina
Zdroj: Psychiatry research. Neuroimaging [Psychiatry Res Neuroimaging] 2024 Jun; Vol. 340, pp. 111809. Date of Electronic Publication: 2024 Mar 23.
DOI: 10.1016/j.pscychresns.2024.111809
Abstrakt: Alcohol use disorder is associated with overvaluation of alcohol relative to other rewards, in part due to dynamic increases in value in response to alcohol-related cues. In a neuroeconomic framework, alcohol cues increase behavioral economic demand for alcohol, but the neural correlates these cue effects are unknown. This functional magnetic resonance imaging study combined a neuroeconomic alcohol purchase task with an alcohol cue exposure in 72 heavy drinkers with established sensitivity to alcohol cues (51 % female; mean age=33.74). Participants reported how many drinks they would consume from $0-$80/drink following exposure to neutral and alcohol images in a fixed order. Participants purchased significantly more drinks in the alcohol compared to the neutral condition, which was also evident for demand indices (i.e., intensity, breakpoint, Omax, elasticity; ps<0.001; ds=0.46-0.92). Alcohol purchase decisions were associated with activation in rostral middle and medial frontal gyri, anterior insula, posterior parietal cortex, and dorsal striatum, among other regions. Activation was lower across regions in the alcohol relative to neutral cue condition, potentially due to greater automaticity of choices in the presence of alcohol cues or attenuation of responses due to fixed cue order. These results contribute to growing literature using neuroeconomics to understand alcohol misuse and provide a foundation for future research investigating decision-making effects of environmental alcohol triggers.
Competing Interests: Declaration of competing interest J.M. is a Principal and Senior Scientist with Beam Diagnostics, Inc. and a Consultant to Clairvoyant Therapeutics, Inc. Neither organization had any role in the current research. The remaining authors have no conflicts of interest to disclose.
(Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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