Early-Onset Colorectal Cancer in Egypt: Pathological Characters, Patterns of Care, and Survival Compared to Average-Age Onset Colorectal Cancer: A Retrospective Multicenter Study.

Autor:	Rashad N; Medical Oncology Department, Shefaa Al-Orman Oncology Hospital, Luxor, Egypt.; Clinical Oncology Department, Faculty of Medicine, Suez University, Suez, Egypt., Eid Salem S; Department of Medical Oncology, National Cancer Institute (NCI), Cairo University, Cairo, Egypt., Meheissen MAM; Clinical Oncology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.; Hope Cancer Center, Alexandria, Egypt., Refaat G; Clinical Oncology and Nuclear Medicine Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Mahmoud Sami H; Department of Medical Oncology, National Cancer Institute (NCI), Cairo University, Cairo, Egypt., Temerik A; Medical Oncology Department, Shefaa Al-Orman Oncology Hospital, Luxor, Egypt., Kordy N; Biostatistics, Epidemiology and Science Computing Department, Shefaa Al-Orman Oncology Hospital, Luxor, Egypt., Daniel MA; Medical Oncology Department, Shefaa Al-Orman Oncology Hospital, Luxor, Egypt., El-Kaffas M; Medical Oncology Department, Shefaa Al-Orman Oncology Hospital, Luxor, Egypt., Esam M; Medical Oncology Department, Shefaa Al-Orman Oncology Hospital, Luxor, Egypt., El Mansy H; Department of Cancer Management and Research, Medical Research Institute, University of Alexandria, Alexandria, Egypt.; Specialized Universal Network of Oncology (SUN), Alexandria, Egypt., Elkerm Y; Department of Cancer Management and Research, Medical Research Institute, University of Alexandria, Alexandria, Egypt.; Specialized Universal Network of Oncology (SUN), Alexandria, Egypt., Abdelaziz Elsaid A; Clinical Oncology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.; Specialized Universal Network of Oncology (SUN), Alexandria, Egypt., Attia Ismail A; Clinical Oncology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.; Specialized Universal Network of Oncology (SUN), Alexandria, Egypt., Saber Abdelhalim M; Clinical Oncology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt., Moustafa Ahmad L; Clinical Oncology and Nuclear Medicine Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Akram Mahmoud M; Clinical Oncology and Nuclear Medicine Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt., El Desouky ED; Department of Biostatistics and Epidemiology, National Cancer Institute, Cairo University, Cairo, Egypt.
Jazyk:	angličtina
Zdroj:	JCO global oncology [JCO Glob Oncol] 2024 Mar; Vol. 10, pp. e2300372.
DOI:	10.1200/GO.23.00372
Abstrakt:	Purpose: Early-onset colorectal cancer (EOCRC) is a rising health problem. The incidence of EOCRC has increased over the past 2 decades all over the world. Reports from Egypt since the 1990s have reported a higher incidence among young populations with no identifiable risk factors. The aim of this study was to assess EOCRC in Egypt regarding incidence, characteristics, treatment pattern, and survival compared with average age onset and elderly patients. Materials and Methods: This was a retrospective, record-based, cohort study combining data from four different cancer centers in Egypt. We grouped patients according to age into three categories: the EOCRC group for patients age ≤45 years and the average age onset and elderly cancer group (for patients age ≥65 years). Results: The study included 1,310 patients with histopathologically proven colorectal cancer, representing four different geographical areas in Egypt. Patients with EOCRC represented 42.4% of the study population. Female patients were 50.6% among the EOCRC group and 52.5% among the average age group. Rectal tumors were significantly higher in EOCRC (54.7% v 40.6%; P < .001). There was no significant difference between both groups regarding the tumor stage at presentation, obstruction, or presence of metastases at presentation. Patients with EOCRC had a significantly higher rate of peritoneum/adnexa metastases than the average age ones (12.3% in EOCRC v 6.9% in the average age group; P < .001). No statistically significant differences between EOCRC and average age groups in both disease-free survival and overall survival were reported. Conclusion: A comprehensive framework for the study of EOCRC is required in Egypt as well as a genomic analysis to identify possible underlying genetic alterations responsible for the high incidence of EOCRC.
Databáze:	MEDLINE
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