Pillar[6]MaxQ functions as an in vivo sequestrant for rocuronium and vecuronium.
| Autor: | Zhang W; College of Pharmacy, Chongqing Medical University, Chongqing 400016, P. R. China. xiangjunzhang@cqmu.edu.cn., Bazan-Bergamino EA; Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, USA. LIsaacs@umd.edu., Doan AP; Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, USA. LIsaacs@umd.edu., Zhang X; College of Pharmacy, Chongqing Medical University, Chongqing 400016, P. R. China. xiangjunzhang@cqmu.edu.cn., Isaacs L; Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, USA. LIsaacs@umd.edu. |
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| Jazyk: | angličtina |
| Zdroj: | Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2024 Apr 16; Vol. 60 (32), pp. 4350-4353. Date of Electronic Publication: 2024 Apr 16. |
| DOI: | 10.1039/d4cc00772g |
| Abstrakt: | The binding affinity of pillar[6]MaxQ toward a panel of neuromuscular blockers and neurotransmitters was measured in phosphate buffered saline by isothermal titration calorimetry and 1 H NMR spectroscopy. In vivo efficacy studies showed that P6MQ sequesters rocuronium and vecuronium and reverses their influence on the recovery of the train-of-four (TOF) ratio. |
| Databáze: | MEDLINE |
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