Parietal theta burst TMS does not modulate bistable perception.

Autor:	Schauer G; Department of Psychology, University of Tübingen, Schleichstraße 4, Tübingen 72076, Germany.; Centre for Integrative Neuroscience, Otfried-Müller-Straße 25, Tübingen 72076, Germany.; Department for High-Field Magnetic Resonance, Max-Planck Institute for Biological Cybernetics, Max-Planck-Ring 11, Tübingen 72076, Germany., Grassi PR; Department of Psychology, University of Tübingen, Schleichstraße 4, Tübingen 72076, Germany.; Centre for Integrative Neuroscience, Otfried-Müller-Straße 25, Tübingen 72076, Germany.; Department for High-Field Magnetic Resonance, Max-Planck Institute for Biological Cybernetics, Max-Planck-Ring 11, Tübingen 72076, Germany., Gharabaghi A; Institute for Neuromodulation and Neurotechnology, University of Tübingen, Otfried-Müller-Straße 45, 72076, Germany., Bartels A; Department of Psychology, University of Tübingen, Schleichstraße 4, Tübingen 72076, Germany.; Centre for Integrative Neuroscience, Otfried-Müller-Straße 25, Tübingen 72076, Germany.; Department for High-Field Magnetic Resonance, Max-Planck Institute for Biological Cybernetics, Max-Planck-Ring 11, Tübingen 72076, Germany.
Jazyk:	angličtina
Zdroj:	Neuroscience of consciousness [Neurosci Conscious] 2024 Mar 17; Vol. 2024 (1), pp. niae009. Date of Electronic Publication: 2024 Mar 17 (Print Publication: 2024).
DOI:	10.1093/nc/niae009
Abstrakt:	The role of the parietal cortex in perceptual awareness and in resolving perceptual ambiguity is unsettled. Early influential transcranial magnetic stimulation studies have revealed differences in conscious perception following parietal stimulation, fuelling the notion that parietal cortex causally contributes to resolving perceptual ambiguity. However, central to this conclusion is the reliability of the method employed. Several prior studies have revealed opposing effects, such as shortening, lengthening, or no effect on multistable perceptual transitions following parietal stimulation. Here we addressed the reliability of continuous theta-burst stimulation (cTBS) on parietal cortex on the perception of bistable stimuli. We conducted three cTBS experiments that were matched to prior experiments in terms of stimuli, stimulation protocol, and target site, and used a higher number of participants. None of our cTBS experiments replicated prior cTBS results. The only experiment using individual functional localizers led to weak effects, while the two others led to null results. Individual variability of motor cortex cTBS did not predict parietal cTBS effects. In view of recent reports of highly variable cTBS effects over motor cortex, our results suggest that cTBS is particularly unreliable in modulating bistable perception when applied over parietal cortex. Competing Interests: None declared. (© The Author(s) 2024. Published by Oxford University Press.)
Databáze:	MEDLINE
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