Nonlinear optical and spectroscopic properties, thermal analysis, and hemolytic capacity evaluation of quinoline-1,3-benzodioxole chalcone.

Autor: Polo-Cuadrado E; Depto. Química Orgánica, Fac. Ciencias Químicas, Universidad de Concepción Chile., Osorio E; Facultad de Ciencias Naturales y Matemáticas, Universidad de Ibagué Carrera 22 Calle 67 Ibagué 730001 Colombia., Acosta-Quiroga K; Departamento de Química Orgánica y Fisicoquímica, Doctorado en Química, Universidad de Chile Santiago Chile., Camargo-Ayala PA; Departamento de Ciencias Básicas Biomédicas, Facultad de Ciencias de la Salud, Universidad de Talca Talca Chile., Brito I; Departamento de Química, Facultad de Ciencias Básicas, Universidad de Antofagasta, Avda Campus Coloso Antofagasta 02800 Chile., Rodriguez J; Doctorado en Ciencias Mención I + D de Productos Bioactivos, Instituto de Química de Recursos Naturales, Universidad de Talca Casilla 747 Talca 3460000 Chile., Alderete JB; Instituto de Química de Recursos Naturales (IQRN), Universidad de Talca Avenida Lircay S/N, Casilla 747 Talca Chile., Forero-Doria O; Departamento de Ciencias Básicas, Facultad de Ciencias, Universidad Santo Tomás Talca 3460000 Chile., Blanco-Acuña EF; Grupo de Investigación en Ciencias Básicas (NÚCLEO), Facultad de Ciencias e Ingeniería, Universidad de Boyacá 150003 Tunja Boyacá Colombia efblanco@uniboyaca.edu.co., Gutiérrez M; Laboratorio Síntesis Orgánica y Actividad Biológica (LSO-Act-Bio), Instituto de Química de Recursos Naturales, Universidad de Talca Casilla 747 Talca 3460000 Chile mgutierrez@utalca.cl.
Jazyk: angličtina
Zdroj: RSC advances [RSC Adv] 2024 Mar 27; Vol. 14 (15), pp. 10199-10208. Date of Electronic Publication: 2024 Mar 27 (Print Publication: 2024).
DOI: 10.1039/d4ra00820k
Abstrakt: This article describes the synthesis, characterization ( 1 H NMR, 13 C NMR, FT-IR, HRMS and XRD), UV-Vis absorption and fluorescence spectra, theoretical analysis, evaluation of nonlinear optical properties (NLO), thermal analysis and determination of the hemolytic capacity of the compound ( E )- N -(4-(3-(benzo[ d ][1,3]dioxol-5-yl)acryloyl)phenyl)quinoline-3-carboxamide (5). Radiological findings showed that compound 5 crystallized in space group Pca 2 1 . Furthermore, theoretical DFT studies performed with the B3LYP and M062X functionals showed good agreement with the experimental results and provided valuable information on the molecular and electronic structure, reactivity, polarizability, and kinematic stability of the compound. Besides, compound 5 did not show any hemolytic effect on human erythrocytes and exhibited strong NLO properties. The TG and DTA thermograms of quinoline-chalcone (5) revealed a multi-step thermal decomposition process with a total mass loss of 83.2%, including water content loss. The DTA curves exhibited endothermic peaks corresponding to decomposition steps, melting point, and thermochemical transition. Additionally, exothermic peaks in the DTA thermograms align with significant mass loss, confirming the compound's melting point and water content, as validated by X-ray diffraction analysis. These results contribute to the advancement of research on compounds with NLO properties and offer a promising avenue for the development of substances potentially applicable to optical devices in the biomedical field.
Competing Interests: There are no conflicts to declare.
(This journal is © The Royal Society of Chemistry.)
Databáze: MEDLINE
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