Poliovirus-Neutralizing Antibody Seroprevalence and Vaccine Habits in a Vaccine-Derived Poliovirus Outbreak Region in the Democratic Republic of Congo in 2018: The Impact on the Global Eradication Initiative.

Autor: Halbrook M; Department of Epidemiology, Jonathan and Karin Fielding School of Public Health, University of California, Los Angeles, CA 90095, USA., Gadoth A; Department of Epidemiology, Jonathan and Karin Fielding School of Public Health, University of California, Los Angeles, CA 90095, USA., Mukadi P; National Institute of Biomedical Research, Kinshasa P.O. Box 1197, Democratic Republic of the Congo., Hoff NA; Department of Epidemiology, Jonathan and Karin Fielding School of Public Health, University of California, Los Angeles, CA 90095, USA., Musene K; Department of Epidemiology, Jonathan and Karin Fielding School of Public Health, University of California, Los Angeles, CA 90095, USA., Dzogang C; National Institute of Biomedical Research, Kinshasa P.O. Box 1197, Democratic Republic of the Congo., Sinai CS; Carolina Population Center, University of North Carolina, Chapel Hill, NC 27516, USA., Spencer D; Children's National Research Institute, Center for Genetic Medicine Research, 111 Michigan Avenue NW, Washington, DC 20010, USA., Ngoie-Mwamba G; Expanded Programme for Immunization, Kinshasa P.O. Box 1197, Democratic Republic of the Congo., Tangney S; Department of Epidemiology, Jonathan and Karin Fielding School of Public Health, University of California, Los Angeles, CA 90095, USA., Salet F; Bill and Melinda Gates Foundation, Seattle, WA 98109, USA., Nyembwe M; Expanded Programme for Immunization, Kinshasa P.O. Box 1197, Democratic Republic of the Congo., Kambamba Nzaji M; Expanded Programme for Immunization, Kinshasa P.O. Box 1197, Democratic Republic of the Congo., Tambu M; National Institute of Biomedical Research, Kinshasa P.O. Box 1197, Democratic Republic of the Congo., Mbala P; National Institute of Biomedical Research, Kinshasa P.O. Box 1197, Democratic Republic of the Congo., Fuller T; Institute of the Environment and Sustainability, University of California, Los Angeles, CA 90095, USA., Gerber SK; Institute of the Environment and Sustainability, University of California, Los Angeles, CA 90095, USA., Kaba D; Kinshasa School of Public Health, University of Kinshasa, Kinshasa P.O. Box 11850, Democratic Republic of the Congo., Muyembe-Tamfum JJ; National Institute of Biomedical Research, Kinshasa P.O. Box 1197, Democratic Republic of the Congo., Rimoin AW; Department of Epidemiology, Jonathan and Karin Fielding School of Public Health, University of California, Los Angeles, CA 90095, USA.
Jazyk: angličtina
Zdroj: Vaccines [Vaccines (Basel)] 2024 Feb 27; Vol. 12 (3). Date of Electronic Publication: 2024 Feb 27.
DOI: 10.3390/vaccines12030246
Abstrakt: Despite the successes in wild-type polio eradication, poor vaccine coverage in the DRC has led to the occurrence of circulating vaccine-derived poliovirus outbreaks. This cross-sectional population-based survey provides an update to previous poliovirus-neutralizing antibody seroprevalence studies in the DRC and quantifies risk factors for under-immunization and parental knowledge that guide vaccine decision making. Among the 964 children between 6 and 35 months in our survey, 43.8% (95% CI: 40.6-47.0%), 41.1% (38.0-44.2%), and 38.0% (34.9-41.0%) had protective neutralizing titers to polio types 1, 2, and 3, respectively. We found that 60.7% of parents reported knowing about polio, yet 25.6% reported knowing how it spreads. Our data supported the conclusion that polio outreach efforts were successfully connecting with communities-79.4% of participants had someone come to their home with information about polio, and 88.5% had heard of a polio vaccination campaign. Additionally, the odds of seroreactivity to only serotype 2 were far greater in health zones that had a history of supplementary immunization activities (SIAs) compared to health zones that did not. While SIAs may be reaching under-vaccinated communities as a whole, these results are a continuation of the downward trend of seroprevalence rates in this region.
Databáze: MEDLINE