Evaluation of Vaccine Immunogenicity-Correlates to Real-World Protection: Influenza.

Autor: Laszlofy C; Department of Prosthodontics, Faculty of Dentistry, University of Szeged, 6720 Szeged, Hungary., Fazekas G; Fluart Innovations Ltd., 2097 Pilisborosjeno, Hungary., Barath Z; Department of Prosthodontics, Faculty of Dentistry, University of Szeged, 6720 Szeged, Hungary., Vajo Z; Department of Family Medicine, Semmelweis University Medical School, 1085 Budapest, Hungary.
Jazyk: angličtina
Zdroj: Viruses [Viruses] 2024 Mar 12; Vol. 16 (3). Date of Electronic Publication: 2024 Mar 12.
DOI: 10.3390/v16030441
Abstrakt: Recent events highlighted that, despite decades of studying vaccine immunogenicity and efforts toward finding correlates of protection, evaluating real-world vaccine efficacy as well as establishing meaningful licensing criteria still represents a significant challenge. In this paper, we review all aspects of influenza vaccine immunogenicity, including animal and human challenge studies, humoral and cellular immunity parameters, and their potential correlation with real-life protection from disease.
Databáze: MEDLINE
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