| Autor: |
Rodio M; Plastic Surgery Unit, University Hospital Trust of Sassari, 07100 Sassari, Italy.; Plastic, Reconstructive and Aesthetic Surgery Training Program, University of Sassari, 07100 Sassari, Italy., Tettamanzi M; Plastic Surgery Unit, University Hospital Trust of Sassari, 07100 Sassari, Italy.; Plastic, Reconstructive and Aesthetic Surgery Training Program, University of Sassari, 07100 Sassari, Italy., Trignano E; Plastic Surgery Unit, University Hospital Trust of Sassari, 07100 Sassari, Italy.; Department of Medicine, Surgery and Pharmacy, University of Sassari, 07100 Sassari, Italy., Rampazzo S; Plastic Surgery Unit, University Hospital Trust of Sassari, 07100 Sassari, Italy.; Plastic, Reconstructive and Aesthetic Surgery Training Program, University of Sassari, 07100 Sassari, Italy., Serra PL; Plastic Surgery Unit, University Hospital Trust of Sassari, 07100 Sassari, Italy.; Plastic, Reconstructive and Aesthetic Surgery Training Program, University of Sassari, 07100 Sassari, Italy., Grieco F; Plastic Surgery Unit, University Hospital Trust of Sassari, 07100 Sassari, Italy.; Plastic, Reconstructive and Aesthetic Surgery Training Program, University of Sassari, 07100 Sassari, Italy., Boccaletti R; Department of Neurosurgery, Azienda Ospedaliero Universitaria di Sassari, 07100 Sassari, Italy., Veneziani Santonio F; Department of Neurosurgery, Azienda Ospedaliero Universitaria di Sassari, 07100 Sassari, Italy., Fadda GM; Unità Operativa Complessa di Oncologia Medica, Azienda Ospedaliera Universitaria di Sassari, 07100 Sassari, Italy., Sanna F; Radiotherapy Department, Sassari Hospital, University of Sassari, 07100 Sassari, Italy., Di Mario D; Radiotherapy Department, Sassari Hospital, University of Sassari, 07100 Sassari, Italy., Rubino C; Plastic Surgery Unit, University Hospital Trust of Sassari, 07100 Sassari, Italy.; Department of Medicine, Surgery and Pharmacy, University of Sassari, 07100 Sassari, Italy. |
| Abstrakt: |
Background : Scalp-associated cutaneous squamous cell carcinoma (cSCC) presents formidable treatment challenges, especially when it leads to full-thickness defects involving bone. Aggressive or recurring cases often demand a multidisciplinary approach. Leveraging our surgical experience and a literature review, we introduce a therapeutic algorithm to guide the selection of reconstruction methods, particularly for locally advanced lesions, furthermore showing the synergy between surgery and other therapies for comprehensive, multidisciplinary disease management. Methods : Our algorithm stems from a retrospective analysis of 202 patients undergoing scalp cSCC resection and reconstruction over a 7-year period, encompassing 243 malignancies. After rigorous risk assessment and documentation of surgical procedures, reconstruction methods were therefore related to malignancy extent, depth, and individual clinical status. Results : The documented reconstructions included 76 primary closures, 115 skin grafts, 7 dermal substitute reconstructions, 33 local flaps, 1 locoregional flap, and 1 microsurgical free flap. Patients unsuitable for surgery received radiotherapy or immunotherapy after histological confirmation. Precise analysis of tumor characteristics in terms of infiltration extent and depth guided the selection of appropriate reconstruction and treatment strategies Combining these insights with an extensive literature review enabled us to formulate our algorithm for managing scalp cSCCs. Conclusions : Effectively addressing scalp cSCC, especially in locally advanced or recurrent cases, demands a systematic approach integrating surgery, radiotherapy, and immunotherapy. Our multidisciplinary team's decision-making algorithm improved patient outcomes by offering a broader spectrum of therapeutic options that can synergistically achieve optimal results. |
