Modern Treatment of Valvulopathies in Patients with Congenital Hemophilia.

Autor: Badescu MC; Department of Internal Medicine, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.; III Internal Medicine Clinic, 'St. Spiridon' County Emergency Clinical Hospital, 700111 Iasi, Romania., Badulescu OV; Department of Pathophysiology, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.; Hematology Clinic, 'St. Spiridon' County Emergency Clinical Hospital, 700111 Iasi, Romania., Gheorghe L; Department of Radiology, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.; Radiology Clinic, 'St. Spiridon' County Emergency Clinical Hospital, 700111 Iasi, Romania., Butnariu LI; Department of Mother and Child Medicine, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania., Ouatu A; Department of Internal Medicine, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.; III Internal Medicine Clinic, 'St. Spiridon' County Emergency Clinical Hospital, 700111 Iasi, Romania., Popescu D; Department of Internal Medicine, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.; III Internal Medicine Clinic, 'St. Spiridon' County Emergency Clinical Hospital, 700111 Iasi, Romania., Buliga-Finiș ON; Department of Internal Medicine, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.; III Internal Medicine Clinic, 'St. Spiridon' County Emergency Clinical Hospital, 700111 Iasi, Romania., Gorduza EV; Department of Mother and Child Medicine, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania., Ciocoiu M; Department of Pathophysiology, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania., Rezus C; Department of Internal Medicine, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.; III Internal Medicine Clinic, 'St. Spiridon' County Emergency Clinical Hospital, 700111 Iasi, Romania.
Jazyk: angličtina
Zdroj: Life (Basel, Switzerland) [Life (Basel)] 2024 Mar 07; Vol. 14 (3). Date of Electronic Publication: 2024 Mar 07.
DOI: 10.3390/life14030354
Abstrakt: Hemophiliacs can develop cardiovascular diseases, including valvulopathies of various etiologies and severities. Some require surgical treatment. Performing cardiac surgery in hemophiliacs is a challenge because they maintain an increased risk of bleeding throughout their lives. Our review shows that with a multidisciplinary team and careful planning, cardiac surgery can be safely performed in these patients. Valve repair and bioprosthetic valves should be preferred over mechanical valves to avoid life-long anticoagulation. In patients who cannot receive a bioprosthetic valve, the use of the On-X mechanical valve might be considered because it requires less intensive anticoagulation after 3 months of treatment. Antithrombotic treatment is feasible in hemophiliacs only if the coagulation factor level is kept constantly above a specific trough limit. Our review is valuable because, for the first time, the available data on the modern surgical treatment of valvular disease in hemophiliacs have been synthesized and systematized.
Databáze: MEDLINE
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