| Autor: |
Júnior ASS; Department of Pharmaceutical Sciences, Federal University of Sergipe, São Cristóvão 49100-000, Sergipe, Brazil., Aidar FJ; Department of Physical Education, Federal University of Sergipe, São Cristóvão 49100-000, Sergipe, Brazil., Silva LAS; Department of Pharmaceutical Sciences, Federal University of Sergipe, São Cristóvão 49100-000, Sergipe, Brazil., de B Silva T; Department of Pharmaceutical Sciences, Federal University of Sergipe, São Cristóvão 49100-000, Sergipe, Brazil., de Almeida SFM; Department of Pharmaceutical Sciences, Federal University of Sergipe, São Cristóvão 49100-000, Sergipe, Brazil., Teles DCS; Department of Pharmaceutical Sciences, Federal University of Sergipe, São Cristóvão 49100-000, Sergipe, Brazil., de L Junior W; Department of Morphology, Federal University of Sergipe, São Cristóvão 49100-000, Sergipe, Brazil., Schimieguel DM; Department of Pharmaceutical Sciences, Federal University of Sergipe, São Cristóvão 49100-000, Sergipe, Brazil., de Souza DA; Department of Physiology, Federal University of Sergipe, São Cristóvão 49100-000, Sergipe, Brazil., Nascimento ACS; Department of Physiology, Federal University of Sergipe, São Cristóvão 49100-000, Sergipe, Brazil., Camargo EA; Department of Physiology, Federal University of Sergipe, São Cristóvão 49100-000, Sergipe, Brazil., Dos Santos JL; Department of Physical Education, Federal University of Sergipe, São Cristóvão 49100-000, Sergipe, Brazil., de O E Silva AM; Department of Nutrition, Federal University of Sergipe, São Cristóvão 49100-000, Sergipe, Brazil., de S Nunes R; Department of Pharmaceutical Sciences, Federal University of Sergipe, São Cristóvão 49100-000, Sergipe, Brazil., Borges LP; Department of Pharmaceutical Sciences, Federal University of Sergipe, São Cristóvão 49100-000, Sergipe, Brazil.; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-220, São Paulo, Brazil., Lira AAM; Department of Pharmaceutical Sciences, Federal University of Sergipe, São Cristóvão 49100-000, Sergipe, Brazil. |
| Abstrakt: |
(1) Background: Species of the genus Cymbopogon and its essential oil are known for their antioxidant and hypoglycemic effects. This study aimed to investigate the impact of the essential oil of Cymbopogon flexuosus (EOCF), and its major component, citral, on glycemic, lipid, antioxidant parameters, and oxidative stress in a type 1 diabetes (DM1) rat model. (2) Methods: Initially, EOCF was analyzed by Gas chromatography-mass spectrometry (GC-MS) and the antioxidant activity of EOCF and citral was evaluated. Next, male Wistar rats (3 months old, 200-250 g) induced with DM1 using Streptozotocin (STZ) were divided into four groups: negative control supplemented with an 80% Tween solution, two groups of animals supplemented with EOCF (32 mg/kg and 64 mg/kg) and with citral (32 mg/kg), and treated for 14 days. Measurements of blood glucose levels and body weight were taken; after euthanasia, biochemical markers, including lipid profile, uric acid, alanine aminotransferase (ALT), and aspartate aminotransferase (AST), were evaluated. (3) Results: The predominant compounds in EOCF were α-citral (53.21%) and neral (19.42%), constituting 72.63% citral. EOCF showed good antioxidant activity, significantly greater than citral. EOCF supplementation demonstrated a mitigating effect on glycemic, lipid, and hepatic abnormalities induced by DM1. (4) Conclusions: EOCF emerges as a promising therapeutic option for the management of DM1. |
