Assessment of Psychometric Characteristics of Parkinson's Disease Sleep Scale 2 and Analysis of a Cut-Off Score for Detecting Insomnia in Italian Patients with Parkinson's Disease: A Validation Study.

Autor:	Liguori C; UOSD Parkinson, Neurology Unit, University Hospital of Rome Tor Vergata, 00133 Rome, Italy.; Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy., Frontani F; Departmental Faculty of Medicine and Surgery, Saint Camillus International University of Rome and Medical Sciences (UniCamillus), 00131 Rome, Italy., Francescangeli G; Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy., Pierantozzi M; UOSD Parkinson, Neurology Unit, University Hospital of Rome Tor Vergata, 00133 Rome, Italy.; Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy., Cerroni R; UOSD Parkinson, Neurology Unit, University Hospital of Rome Tor Vergata, 00133 Rome, Italy.; Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy., Schirinzi T; UOSD Parkinson, Neurology Unit, University Hospital of Rome Tor Vergata, 00133 Rome, Italy.; Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy., Stefani A; UOSD Parkinson, Neurology Unit, University Hospital of Rome Tor Vergata, 00133 Rome, Italy.; Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy., Mercuri NB; UOSD Parkinson, Neurology Unit, University Hospital of Rome Tor Vergata, 00133 Rome, Italy.; Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy., Galeoto G; Department of Human Neurosciences, Sapienza University of Rome, 00185 Rome, Italy.; Neuromed IRCCS, 86077 Pozzilli, Italy.
Jazyk:	angličtina
Zdroj:	Journal of personalized medicine [J Pers Med] 2024 Mar 10; Vol. 14 (3). Date of Electronic Publication: 2024 Mar 10.
DOI:	10.3390/jpm14030298
Abstrakt:	Introduction: Sleep disorders are frequent non-motor symptoms affecting patients with Parkinson's disease (PD). Insomnia represents the most common sleep disorder. Parkinson's disease Sleep Scale 2 (PDSS-2) is a specific tool to investigate sleep problems in PD. The General Sleep Disturbances Scale (GSDS) was a general scale validated for the Italian population. Our goal was to assess the psychometric characteristics of PDSS-2 and the GSDS in this population, calculating a cut-off score for insomnia symptoms by using subitems of PDSS-2. Methods: Patients admitted at the PD Unit of the Hospital of Rome Tor Vergata outpatient clinic and those afferent to PD associations were asked to complete PDSS-2 and GSDS to be correlated to identify a cut-off for insomnia symptoms. Items 1,2,3,8,13 of PDSS-2 were used to detect insomnia. An ROC curve to assess a cut-off score for insomnia was determined. A cross-cultural analysis of PD population characteristics was performed. Results: In total, 350 PD patients were recruited. Cronbach's alpha was high for the total score (0.828 for PDSS-2 and 0.832 for GSDS). A cross-cultural analysis did not show any significant p -value. The ROC curve yielded an AUC of 0.79 (CI: 0.75-0.84). The cut-off value for insomnia disorder based on items 1,2,3,8,13 of PDSS-2 was >10, demonstrating a sensitivity of 76% and a specificity of 69% in determining the presence of subjective insomnia symptoms in PD. Discussion: PDSS-2 is demonstrated to be a valid, specific tool to address sleep disturbances in PD patients. A cut-off score of 10 for items 1,2,3,8,13 was identified for detecting insomnia symptoms in PD patients.
Databáze:	MEDLINE
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