Development of a Novel Endometrial Signature Based on Endometrial microRNA for Determining the Optimal Timing for Embryo Transfer.

Autor:	Chen CH; Institute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu 300, Taiwan.; Department of Obstetrics and Gynecology, Ton Yen General Hospital, Hsinchu 302, Taiwan.; Taiwan IVF Group Center for Reproductive Medicine & Infertility, Hsinchu 302, Taiwan., Lu F; Department of Obstetrics and Gynecology, Ton Yen General Hospital, Hsinchu 302, Taiwan.; Taiwan IVF Group Center for Reproductive Medicine & Infertility, Hsinchu 302, Taiwan., Yang WJ; Department of Obstetrics and Gynecology, Ton Yen General Hospital, Hsinchu 302, Taiwan.; Taiwan IVF Group Center for Reproductive Medicine & Infertility, Hsinchu 302, Taiwan., Chen WM; Inti Labs, Hsinchu 302, Taiwan., Yang PE; Inti Labs, Hsinchu 302, Taiwan., Kang ST; Pharus Taiwan, Inc., Hsinchu 302, Taiwan., Wang T; Inti Labs, Hsinchu 302, Taiwan., Chang PC; Quark Biosciences Taiwan, Inc., Hsinchu 302, Taiwan., Feng CT; Quark Biosciences Taiwan, Inc., Hsinchu 302, Taiwan., Yang JH; Inti Labs, Hsinchu 302, Taiwan., Liu CY; Taiwan IVF Group Center for Reproductive Medicine & Infertility, Hsinchu 302, Taiwan., Hsieh CA; Taiwan IVF Group Center for Reproductive Medicine & Infertility, Hsinchu 302, Taiwan., Wang LH; Institute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu 300, Taiwan.; Department of Medical Science, National Tsing Hua University, Hsinchu 300, Taiwan.; School of Medicine, National Tsing Hua University, Hsinchu 300, Taiwan., Huang JY; Department of Obstetrics and Gynecology, Ton Yen General Hospital, Hsinchu 302, Taiwan.; Taiwan IVF Group Center for Reproductive Medicine & Infertility, Hsinchu 302, Taiwan.; Division of Reproductive Endocrinology and Infertility, Stanford University, Stanford, CA 94305, USA.
Jazyk:	angličtina
Zdroj:	Biomedicines [Biomedicines] 2024 Mar 21; Vol. 12 (3). Date of Electronic Publication: 2024 Mar 21.
DOI:	10.3390/biomedicines12030700
Abstrakt:	Though tremendous advances have been made in the field of in vitro fertilization (IVF), a portion of patients are still affected by embryo implantation failure issues. One of the most significant factors contributing to implantation failure is a uterine condition called displaced window of implantation (WOI), which refers to an unsynchronized endometrium and embryo transfer time for IVF patients. Previous studies have shown that microRNAs (miRNAs) can be important biomarkers in the reproductive process. In this study, we aim to develop a miRNA-based classifier to identify the WOI for optimal time for embryo transfer. A reproductive-related PanelChip ® was used to obtain the miRNA expression profiles from the 200 patients who underwent IVF treatment. In total, 143 out of the 167 miRNAs with amplification signals across 90% of the expression profiles were utilized to build a miRNA-based classifier. The microRNA-based classifier identified the optimal timing for embryo transfer with an accuracy of 93.9%, a sensitivity of 85.3%, and a specificity of 92.4% in the training set, and an accuracy of 88.5% in the testing set, showing high promise in accurately identifying the WOI for the optimal timing for embryo transfer.
Databáze:	MEDLINE
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