Characterization of Thyroid Cancer among Hispanics in California, USA, from 2010 to 2020.

Autor: Hsu RC; Department of Internal Medicine, Division of Medical Oncology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA., Tsai KY; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA., Benjamin DJ; Hoag Family Cancer Institute, Newport Beach, CA 92663, USA., Chennapan K; Department of Internal Medicine, Division of Medical Oncology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA., Wojcik KY; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA., Lee AW; Department of Public Health, California State University, Fullerton, CA 92831, USA., Thomas JS; Department of Internal Medicine, Division of Medical Oncology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA., Nieva JJ; Department of Internal Medicine, Division of Medical Oncology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.; Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA., Liu L; Department of Internal Medicine, Division of Medical Oncology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Jazyk: angličtina
Zdroj: Cancers [Cancers (Basel)] 2024 Mar 08; Vol. 16 (6). Date of Electronic Publication: 2024 Mar 08.
DOI: 10.3390/cancers16061101
Abstrakt: Background: Previous studies on Hispanic thyroid cancer cases show sex disparities and an increased prevalence of large tumor sizes and nodal involvement. Here, we characterized Hispanic thyroid cancer cases in California.
Methods: We identified thyroid cancer cases from 2010 to 2020 using the California Cancer Registry by sex, race/ethnicity, histology, TNM stage, tumor size, lymph node involvement, and Charlson comorbidity score. The age-adjusted incidence rate (AAIR) and age-adjusted mortality rate (AAMR) for all causes of death were calculated. A Cox proportional hazards regression analysis was performed to evaluate the mortality risk from all causes of death by race.
Results: Overall, 56,838 thyroid cancer cases were identified, including 29.75% in Hispanics. Hispanics had the highest female-to-male incidence rate ratio (IRR 3.54) and the highest prevalence of T3/T4 tumor size (28.71%), the highest N1 nodal status (32.69%), and the highest AAMR (0.79 per 100,000 people). After adjusting for demographic and tumor covariates, compared to non-Hispanic White people, Hispanic ethnicity, with an HR of 1.22 (95% CI 1.18-1.25, p < 0.0001), remained a significant independent contributor to mortality risk.
Conclusions: Hispanics had the greatest female-to-male IRR ratio, a greater prevalence of advanced disease features at diagnosis, along with the highest AAMR and increased mortality risk despite adjustments for demographic and tumor covariates. Further investigation into other risk factors is needed.
Databáze: MEDLINE
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