Telocytes: current methods of research, challenges and future perspectives.

Autor: Sanches BDA; Department of Structural and Functional Biology, Institute of Biology, State University of Campinas (UNICAMP), Carl von Linnaeus St. Bldg G1, Bertrand Russel Ave., Campinas, São Paulo, Brazil., Teófilo FBS; Department of Structural and Functional Biology, Institute of Biology, State University of Campinas (UNICAMP), Carl von Linnaeus St. Bldg G1, Bertrand Russel Ave., Campinas, São Paulo, Brazil., Brunet MY; School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK., Villapun VM; School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK., Man K; Department of Oral and Maxillofacial Surgery & Special Dental Care, University Medical Center Utrecht, Utrecht University, Utrecht, 3508 GA, The Netherlands.; Regenerative Medicine Center Utrecht, Utrecht, 3584 CT, The Netherlands., Rocha LC; Laboratory of Morphology and Physical Activity (LAMAF), Institute of Biosciences, São Paulo State University (UNESP), 1515 24 A Ave., Rio Claro, São Paulo, Brazil., Neto JP; Laboratory of Morphology and Physical Activity (LAMAF), Institute of Biosciences, São Paulo State University (UNESP), 1515 24 A Ave., Rio Claro, São Paulo, Brazil., Matsumoto MR; Department of Structural and Functional Biology, Institute of Biology, State University of Campinas (UNICAMP), Carl von Linnaeus St. Bldg G1, Bertrand Russel Ave., Campinas, São Paulo, Brazil., Maldarine JS; Department of Structural and Functional Biology, Institute of Biology, State University of Campinas (UNICAMP), Carl von Linnaeus St. Bldg G1, Bertrand Russel Ave., Campinas, São Paulo, Brazil., Ciena AP; Laboratory of Morphology and Physical Activity (LAMAF), Institute of Biosciences, São Paulo State University (UNESP), 1515 24 A Ave., Rio Claro, São Paulo, Brazil., Cox SC; School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK., Carvalho HF; Department of Structural and Functional Biology, Institute of Biology, State University of Campinas (UNICAMP), Carl von Linnaeus St. Bldg G1, Bertrand Russel Ave., Campinas, São Paulo, Brazil. hern@unicamp.br.
Jazyk: angličtina
Zdroj: Cell and tissue research [Cell Tissue Res] 2024 May; Vol. 396 (2), pp. 141-155. Date of Electronic Publication: 2024 Mar 28.
DOI: 10.1007/s00441-024-03888-5
Abstrakt: Telocytes (TCs) are CD34-positive interstitial cells that have long cytoplasmic projections, called telopodes; they have been identified in several organs and in various species. These cells establish a complex communication network between different stromal and epithelial cell types, and there is growing evidence that they play a key role in physiology and pathology. In many tissues, TC network impairment has been implicated in the onset and progression of pathological conditions, which makes the study of TCs of great interest for the development of novel therapies. In this review, we summarise the main methods involved in the characterisation of these cells as well as their inherent difficulties and then discuss the functional assays that are used to uncover the role of TCs in normal and pathological conditions, from the most traditional to the most recent. Furthermore, we provide future perspectives in the study of TCs, especially regarding the establishment of more precise markers, commercial lineages and means for drug delivery and genetic editing that directly target TCs.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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