Chemoprofiling and medicinal potential of underutilized leaves of Cyperus scariosus.

Autor: Gandhi Y; Central Ayurveda Research Institute, Jhansi, Uttar Pradesh, 284003, India., Kumar V; Central Ayurveda Research Institute, Jhansi, Uttar Pradesh, 284003, India. vijaychem99@gmail.com., Singh G; Central Ayurveda Research Institute, Jhansi, Uttar Pradesh, 284003, India., Prasad SB; Central Ayurveda Research Institute, Jhansi, Uttar Pradesh, 284003, India., Mishra SK; Central Ayurveda Research Institute, Jhansi, Uttar Pradesh, 284003, India., Soni H; Central Ayurveda Research Institute, Jhansi, Uttar Pradesh, 284003, India., Rawat H; Central Ayurveda Research Institute, Jhansi, Uttar Pradesh, 284003, India., Singh S; Interdisciplinary Centre for Water Research, Indian Institute of Sciences, Bangalore, 560012, India. simnav14@gmail.com., Charde V; Central Ayurveda Research Institute, Jhansi, Uttar Pradesh, 284003, India., Gupta A; Central Ayurveda Research Institute, Jhansi, Uttar Pradesh, 284003, India., Dhanjal DS; Lovely Professional University, Phagwara, Punjab, 144411, India., Jha SK; Central Ayurveda Research Institute, Jhansi, Uttar Pradesh, 284003, India., Tandon S; Central Ayurveda Research Institute, Jhansi, Uttar Pradesh, 284003, India., Bhagwat P; Central Ayurveda Research Institute, Jhansi, Uttar Pradesh, 284003, India., Arya JC; Central Ayurveda Research Institute, Jhansi, Uttar Pradesh, 284003, India., Ramamurthy PC; Interdisciplinary Centre for Water Research, Indian Institute of Sciences, Bangalore, 560012, India., Acharya R; Central Council for Research in Ayurvedic Sciences, New Delhi, 110058, India., Narasimhaji CV; Central Ayurveda Research Institute, Jhansi, Uttar Pradesh, 284003, India., Singh A; Central Council for Research in Ayurvedic Sciences, New Delhi, 110058, India., Singh R; Central Council for Research in Ayurvedic Sciences, New Delhi, 110058, India., Srikanth N; Central Council for Research in Ayurvedic Sciences, New Delhi, 110058, India., Webster TJ; School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin, China.; School of Engineering, Saveetha University, Chennai, India.; Program in Materials Science, UFPI, Teresina, Brazil.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Mar 27; Vol. 14 (1), pp. 7263. Date of Electronic Publication: 2024 Mar 27.
DOI: 10.1038/s41598-024-58041-7
Abstrakt: Agro-waste is the outcome of the under-utilization of bioresources and a lack of knowledge to re-use this waste in proper ways or a circular economy approach. In the Indian medicinal system, the root of Cyperus scariosus (CS) is used at a large scale due to their vital medicinal properties. Unfortunately, the aerial part of CS is treated as agro-waste and is an under-utilized bioresource. Due to a lack of knowledge, CS is treated as a weed. This present study is the first ever attempt to explore CS leaves as medicinally and a nutrient rich source. To determine the food and nutritional values of the neglected part of Cyperus scariosus R.Br. (CS), i.e. CS leaves, phytochemicals and metal ions of CS were quantified by newly developed HPLC and ICPOES-based methods. The content of the phytochemicals observed in HPLC analysis for caffeic acid, catechin, epicatechin, trans-p-coumaric acid, and trans-ferulic acid was 10.51, 276.15, 279.09, 70.53, and 36.83 µg/g, respectively. In GC-MS/MS analysis, fatty acids including linolenic acid, phytol, palmitic acid, etc. were identified. In ICPOES analysis, the significant content of Na, K, Ca, Cu, Fe, Mg, Mn, and Zn was observed. The TPC and TFC of the CS leaves was 17.933 mg GAE eq./g and 130.767 mg QCE eq./g along with an IC 50 value of 2.78 mg/mL in the DPPH assay and better antacid activity was measured than the standard (CaCO 3 ). The methanolic extract of CS leaves showed anti-microbial activity against Staphylococcus aureus (15 ± 2 mm), Pseudomonas aeruginosa (12 ± 2 mm) and Escherichia coli (10 ± 2 mm). In silico studies confirmed the in vitro results obtained from the antioxidant, antiacid, and anti-microbial studies. In addition, in silico studies revealed the anti-cancerous and anti-inflammatory potential of the CS leaves. This study, thus, demonstrated the medicinal significance of the under-utilized part of CS and the conversion of agro-waste into mankind activity as a pharmaceutical potent material. Consequently, the present study highlighted that CS leaves have medicinal importance with good nutritional utility and have a large potential in the pharmaceutical industry along with improving bio-valorization and the environment.
(© 2024. The Author(s).)
Databáze: MEDLINE
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