Blebology: principles of bleb-based migration.

Autor: García-Arcos JM; Department of Biochemistry, University of Geneva, 1211 Geneva, Switzerland., Jha A; National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA., Waterman CM; National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA., Piel M; Institut Curie, UMR144, CNRS, PSL University, Paris, France; Institut Pierre Gilles de Gennes, PSL University, Paris, France. Electronic address: matthieu.piel@curie.fr.
Jazyk: angličtina
Zdroj: Trends in cell biology [Trends Cell Biol] 2024 Oct; Vol. 34 (10), pp. 838-853. Date of Electronic Publication: 2024 Mar 27.
DOI: 10.1016/j.tcb.2024.02.009
Abstrakt: Bleb-based migration, a conserved cell motility mode, has a crucial role in both physiological and pathological processes. Unlike the well-elucidated mechanisms of lamellipodium-based mesenchymal migration, the dynamics of bleb-based migration remain less understood. In this review, we highlight in a systematic way the establishment of front-rear polarity, bleb formation and extension, and the distinct regimes of bleb dynamics. We emphasize new evidence proposing a regulatory role of plasma membrane-cortex interactions in blebbing behavior and discuss the generation of force and its transmission during migration. Our analysis aims to deepen the understanding of the physical and molecular mechanisms of bleb-based migration, shedding light on its implications and significance for health and disease.
Competing Interests: Declaration of interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence this review.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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