| Autor: |
Ichimaru H; Tsukuba Research Laboratories, Tokuyama Corporation., Kurimoto M; Tsukuba Research Laboratories, Tokuyama Corporation., Kikuchi S; Tsukuba Research Laboratories, Tokuyama Corporation. |
| Jazyk: |
angličtina |
| Zdroj: |
Chemical & pharmaceutical bulletin [Chem Pharm Bull (Tokyo)] 2024; Vol. 72 (3), pp. 340-344. |
| DOI: |
10.1248/cpb.c23-00864 |
| Abstrakt: |
In clinical diagnosis, magnetic polystyrene nanoparticles (MPS NPs) are commonly applied to, e.g., the chemiluminescent immunoassay (CLEIA). However, the conventional preparation method of MPS NPs requires a long duration of heating to form polymer particles, which is inefficient. In this study, we prepared MPS NPs by emulsion solvent-evaporation without heating. We evaluated the effect of the solvent in the water and organic phases on the magnetic particle content. MPS NPs prepared by 4% (v/v) MeOH aqueous solution and adding stearic acid (SA) (4MeSA-MPS NPs) exhibited the highest magnetic particle content. Furthermore, CLEIA analysis indicates that the C-reactive protein detection limit is 80 pg/mL. Thus, 4MeSA-MPS NPs are promising for clinical diagnoses. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
