The difference in endothelium-dependent relaxation components in proximal and distal thoracic aorta regions of male rats.
Autor: | Mezhenskyi OR; Department of Nervous and Muscular Physiology, Bogomoletz Institute of Physiology, Kiyv, Ukraine., Philyppov IB; Department of Nervous and Muscular Physiology, Bogomoletz Institute of Physiology, Kiyv, Ukraine. |
---|---|
Jazyk: | angličtina |
Zdroj: | Physiological reports [Physiol Rep] 2024 Mar; Vol. 12 (6), pp. e15992. |
DOI: | 10.14814/phy2.15992 |
Abstrakt: | Aorta, the largest vessel in the body, is generally considered anatomically homogeneous, yet spatial functional differences exist. In our study, we conducted a comprehensive analysis by reexamining public RNA-SEQ data, comparing expression patterns between thoracic and abdominal aorta. Additionally, we measured acetylcholine-induced relaxations of the different regions of thoracic aorta in Wistar Rats. Our results revealed a distinct percentage difference in acetylcholine-induced relaxation in the proximal and distal segments of the thoracic aorta (p = 1.14e-4). To explain this variation, we performed differential expression analysis of previously published RNA-sequencing data between thoracic and abdominal aorta, which showed 497 differentially expressed genes between these locations. From results of RNA-Seq analysis, we draw a hypothesis that differential expressions of the potassium inward rectifying channels (K (© 2024 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.) |
Databáze: | MEDLINE |
Externí odkaz: | |
Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |