| Autor: |
Perini JA; Research Laboratory of Pharmaceutical Sciences (LAPESF), State University of Rio de Janeiro (UERJ), Rio de Janeiro 23070-200, Brazil.; Laboratório de Educação Profissional em Vigilância em Saúde, Escola Politécnica de Saúde Joaquim Venâncio, Fundação Oswaldo Cruz (EPSJV/Fiocruz), Av. Brasil, 4365-Manguinhos, Rio de Janeiro 21040-900, Brazil., Cardoso JV; Research Laboratory of Pharmaceutical Sciences (LAPESF), State University of Rio de Janeiro (UERJ), Rio de Janeiro 23070-200, Brazil., Knesse AO; Research Laboratory of Pharmaceutical Sciences (LAPESF), State University of Rio de Janeiro (UERJ), Rio de Janeiro 23070-200, Brazil., Pessoa-Silva FO; Research Laboratory of Pharmaceutical Sciences (LAPESF), State University of Rio de Janeiro (UERJ), Rio de Janeiro 23070-200, Brazil., Vasconcellos ACS; Laboratório de Educação Profissional em Vigilância em Saúde, Escola Politécnica de Saúde Joaquim Venâncio, Fundação Oswaldo Cruz (EPSJV/Fiocruz), Av. Brasil, 4365-Manguinhos, Rio de Janeiro 21040-900, Brazil., Machado DE; Research Laboratory of Pharmaceutical Sciences (LAPESF), State University of Rio de Janeiro (UERJ), Rio de Janeiro 23070-200, Brazil., Basta PC; Program of Post-Graduation in Public Health and Environment, National School of Public Health (ENSP), Oswald Cruz Foundation (Fiocruz), Rio de Janeiro 21041-210, Brazil.; Department of Endemic Diseases Samuel Pessoa, ENSP, Fiocruz, Rio de Janeiro 21041-210, Brazil. |
| Abstrakt: |
Mercury (Hg) pollution is a global public health concern because of its adverse effects on the environment and health. Single-nucleotide polymorphisms (SNPs) have been associated with Hg levels and outcomes. The aim of this review was to describe the research and discuss the evidence on the genetic susceptibility of Hg-exposed individuals to the development of neurocognitive disorders. A systematic review was performed to identify the genes/SNPs associated with Hg toxicokinetics and that, therefore, affect neurological function in exposed populations. Observational and experimental studies were identified by screening three databases. Thirteen articles were included (quality score 82-100%) and 8124 individuals were evaluated. Hg exposure was mainly fish consumption (77%) and, in 31% of the studies, the Hg levels exceeded the reference limits. Genetic susceptibility to higher Hg levels and neurotoxicity risk in Hg poisoning were associated with eight ( ALAD rs1800435, CYP3A4 rs2740574, CYP3A5 rs776746, CYP3A7 rs2257401, GSTP1 rs1695, MT1A rs8052394, MT1M rs2270836, and MT4 rs11643815) and three ( MT1A rs8052394, MT1M rs2270837, and MT2A rs10636) SNPs, respectively, and rs8052394 was associated with both outcomes. The MT1A rs8052394 SNP may be used as a susceptibility biomarker to identify individuals at greater risk for higher Hg levels and the development of neurocognitive disorders in metal-exposed populations. |
