| Autor: |
Malsagova KA; Institute of Biomedical Chemistry, 119121 Moscow, Russia., Kopylov AT; Institute of Biomedical Chemistry, 119121 Moscow, Russia., Stepanov AA; Institute of Biomedical Chemistry, 119121 Moscow, Russia., Kulikova LI; Institute of Biomedical Chemistry, 119121 Moscow, Russia.; Institute of Mathematical Problems of Biology RAS-The Branch of Keldysh Institute of Applied Mathematics of Russian Academy of Sciences, 142290 Pushchino, Russia., Izotov AA; Institute of Biomedical Chemistry, 119121 Moscow, Russia., Yurku KA; State Research Center-Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, 119435 Moscow, Russia., Balakin EI; State Research Center-Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, 119435 Moscow, Russia., Pustovoyt VI; State Research Center-Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, 119435 Moscow, Russia., Kaysheva AL; Institute of Biomedical Chemistry, 119121 Moscow, Russia. |
| Abstrakt: |
Proteomic and metabolomic research enables quantitation of the molecular profile of athletes. Multiomic profiling was conducted using plasma samples collected from 18 male athletes performing aerobic activity (running) at high altitude. Metabolomic profiling detected changes in the levels of 4-hydroxyproline, methionine, oxaloacetate, and tyrosine during the recovery period. Furthermore, proteomic profiling revealed changes in expression of proteins contributing to the function of the immune system, muscle damage, metabolic fitness and performance, as well as hemostasis. Further research should focus on developing metabolic models to monitor training intensity and athlete adaptation. |
