| Autor: |
Eshboev F; S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of Uzbekistan, Mirzo Ulugbek Str. 77, Tashkent 100170, Uzbekistan.; School of Chemical Engineering, New Uzbekistan University, Movarounnahr Street 1, Mirzo Ulugbek District, Tashkent 100000, Uzbekistan.; Institute of Fundamental and Applied Research, National Research University TIIAME, 39 Kori Niyoziy Str., Tashkent 100000, Uzbekistan.; Faculty of Biology, National University of Uzbekistan, Tashkent 100174, Uzbekistan., Mamadalieva N; S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of Uzbekistan, Mirzo Ulugbek Str. 77, Tashkent 100170, Uzbekistan.; School of Chemical Engineering, New Uzbekistan University, Movarounnahr Street 1, Mirzo Ulugbek District, Tashkent 100000, Uzbekistan.; Institute of Fundamental and Applied Research, National Research University TIIAME, 39 Kori Niyoziy Str., Tashkent 100000, Uzbekistan., Nazarov PA; A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 1/40 Leninskie Gory, Moscow 119991, Russia., Hussain H; Leibniz Institute of Plant Biochemistry, Department of Bioorganic Chemistry, Weinberg 3, D-06120 Halle, Germany., Katanaev V; Translational Research Center in Oncohaematology, Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, 1211 Geneva, Switzerland.; School of Medicine and Life Sciences, Far Eastern Federal University, Vladivostok 690090, Russia., Egamberdieva D; Institute of Fundamental and Applied Research, National Research University TIIAME, 39 Kori Niyoziy Str., Tashkent 100000, Uzbekistan.; Faculty of Biology, National University of Uzbekistan, Tashkent 100174, Uzbekistan., Azimova S; S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of Uzbekistan, Mirzo Ulugbek Str. 77, Tashkent 100170, Uzbekistan. |
| Abstrakt: |
Infectious diseases are a significant challenge to global healthcare, especially in the face of increasing antibiotic resistance. This urgent issue requires the continuous exploration and development of new antimicrobial drugs. In this regard, the secondary metabolites derived from endophytic microorganisms stand out as promising sources for finding antimicrobials. Endophytic microorganisms, residing within the internal tissues of plants, have demonstrated the capacity to produce diverse bioactive compounds with substantial pharmacological potential. Therefore, numerous new antimicrobial compounds have been isolated from endophytes, particularly from endophytic fungi and actinomycetes. However, only a limited number of these compounds have been subjected to comprehensive studies regarding their mechanisms of action against bacterial cells. Furthermore, the investigation of their effects on antibiotic-resistant bacteria and the identification of biosynthetic gene clusters responsible for synthesizing these secondary metabolites have been conducted for only a subset of these promising compounds. Through a comprehensive analysis of current research findings, this review describes the mechanisms of action of antimicrobial drugs and secondary metabolites isolated from endophytes, antibacterial activities of the natural compounds derived from endophytes against antibiotic-resistant bacteria, and biosynthetic gene clusters of endophytic fungi responsible for the synthesis of bioactive secondary metabolites. |
