| Autor: |
Kamenova K; Institute of Polymers, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria., Prancheva A; Institute of Polymers, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria., Stoyanova S; Open Laboratory on Experimental Micro and Nano Mechanics (OLEM), Institute of Mechanics, Bulgarian Academy of Sciences, Acad. G. Bonchev Str. Block 4, 1113 Sofia, Bulgaria.; Roberval Laboratory for Mechanics, Centre de Recherche de Royallieu, Université de Technologie de Compiègne, 60203 Compiegne, France., Radeva L; Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, Medical University of Sofia, 1000 Sofia, Bulgaria., Tibi IP; Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, Medical University of Sofia, 1000 Sofia, Bulgaria., Yoncheva K; Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, Medical University of Sofia, 1000 Sofia, Bulgaria., Ravutsov MA; Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria., Marinova MK; Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria., Simeonov SP; Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.; Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Ga-ma Pinto, 1649-003 Lisbon, Portugal., Mitova S; The Stephan Angeloff Institute of Microbiology, 1113 Sofia, Bulgaria., Eneva R; The Stephan Angeloff Institute of Microbiology, 1113 Sofia, Bulgaria., Zaharieva MM; The Stephan Angeloff Institute of Microbiology, 1113 Sofia, Bulgaria., Najdenski H; The Stephan Angeloff Institute of Microbiology, 1113 Sofia, Bulgaria., Petrov PD; Institute of Polymers, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria. |
| Abstrakt: |
Hydrogels are superior wound dressings because they can provide protection and hydration of the wound, as well as the controlled release of therapeutic substances to aid tissue regeneration and the healing process. Hydrogels obtained from natural precursors are preferred because of their low cost, biocompatibility, and biodegradability. We describe the synthesis of novel functional hydrogels based on two natural products-citric acid (CA) and pentane-1,2,5-triol (PT, a product from lignocellulose processing) and poly(ethylene glycol) (PEG-600)-via an environment friendly approach. The hydrogels were prepared via monomer crosslinking through a polycondensation reaction at an elevated temperature in the absence of any solvent. The reagents were blended at three different compositions with molar ratios of hydroxyl (from PT and PEG) to carboxyl (from CA) groups of 1:1, 1:1.4, and 1.4:1, respectively. The effect of the composition on the physicomechanical properties of materials was investigated. All hydrogels exhibited pH-sensitive behavior, while the swelling degree and elastic modulus were dependent on the composition of the polymer network. The proteolytic enzyme serratiopeptidase (SER) was loaded into a hydrogel via physical absorption as a model drug. The release profile of SER and the effects of the enzyme on healthy skin cells were assessed. The results showed that the hydrogel carrier could provide the complete release of the loaded enzyme. |
