| Autor: |
Rocha I; Lisbon School of Medicine and CCUL@Rise, Universidade de Lisboa, 1649-028 Lisbon, Portugal., González-García M; Department of Human Physiology, Faculty of Medicine, University of Malaga, 29590 Malaga, Spain.; Unit of Neurophysiology of the Autonomic Nervous System (CIMES), University of Malaga, 29590 Malaga, Spain.; Biomedical Research Institute of Malaga (IBIMA), 29590 Malaga, Spain., Carrillo-Franco L; Department of Human Physiology, Faculty of Medicine, University of Malaga, 29590 Malaga, Spain.; Biomedical Research Institute of Malaga (IBIMA), 29590 Malaga, Spain., Dawid-Milner MS; Department of Human Physiology, Faculty of Medicine, University of Malaga, 29590 Malaga, Spain.; Unit of Neurophysiology of the Autonomic Nervous System (CIMES), University of Malaga, 29590 Malaga, Spain.; Biomedical Research Institute of Malaga (IBIMA), 29590 Malaga, Spain., López-González MV; Department of Human Physiology, Faculty of Medicine, University of Malaga, 29590 Malaga, Spain.; Unit of Neurophysiology of the Autonomic Nervous System (CIMES), University of Malaga, 29590 Malaga, Spain.; Biomedical Research Institute of Malaga (IBIMA), 29590 Malaga, Spain. |
| Abstrakt: |
Area A5 is a noradrenergic cell group in the brain stem characterised by its important role in triggering sympathetic activity, exerting a profound influence on the sympathetic outflow, which is instrumental in the modulation of cardiovascular functions, stress responses and various other physiological processes that are crucial for adaptation and survival mechanisms. Understanding the role of area A5, therefore, not only provides insights into the basic functioning of the sympathetic nervous system but also sheds light on the neuronal basis of a number of autonomic responses. In this review, we look deeper into the specifics of area A5, exploring its anatomical connections, its neurochemical properties and the mechanisms by which it influences sympathetic nervous system activity and cardiorespiratory regulation and, thus, contributes to the overall dynamics of the autonomic function in regulating body homeostasis. |
