Sub-segmental pulmonary thromboembolism in a pregnant woman with generalized lupus erythematosus, triple-negative antiphospholipid syndrome, and protein C deficiency. A case report.

Autor:	Montoya Rodríguez A; Department of Obstetric Critical Care and Internal Medicine, Bertha Calderón Roque Hospital, Managua, Nicaragua., Mayorga Duarte M; Department of Internal Medicine, Hilario Sánchez Vázquez Hospital, Masaya, Nicaragua., López SS; Department of Rheumatology, Manolo Morales Peralta Hospital, Managua, Nicaragua., Obregón VR; Department of Nuclear Medicine, Nora Astorga National Radiotherapy Hospital, Managua, Nicaragua., López Marenco ME; Department of Obstetric Critical Care and Internal Medicine, Bertha Calderón Roque Hospital, Managua, Nicaragua.
Jazyk:	angličtina
Zdroj:	Radiology case reports [Radiol Case Rep] 2024 Mar 18; Vol. 19 (6), pp. 2249-2252. Date of Electronic Publication: 2024 Mar 18 (Print Publication: 2024).
DOI:	10.1016/j.radcr.2024.02.065
Abstrakt:	Autoimmune diseases and thrombophilic disorders, notably antiphospholipid syndrome (APS) and protein S deficiency, present a formidable challenge in pregnancy, substantially increasing the risk of thromboembolic complications by up to 20%. Pulmonary thromboembolism (PTE), characterized by a significantly higher maternal mortality rate, is of particular concern. APS, defined by the presence of antiphospholipid antibodies, emerges as a pivotal risk factor for PTE during pregnancy, especially in women exhibiting triple negativity. Concurrently, protein S deficiency further amplifies vulnerability to thromboembolic events, establishing a high-risk scenario for pregnant individuals. In a case involving a 29-year-old pregnant woman with a history of generalized lupus erythematosus, triple-negative antiphospholipid syndrome, and protein S deficiency, sudden-onset dyspnea prompted thorough investigation. Despite her complex medical history, a multidisciplinary approach led to the accurate diagnosis and successful management of subsegmental pulmonary thromboembolism, ensuring the well-being of both mother and fetus. Effectively managing PTE during pregnancy demands a comprehensive, multidisciplinary approach involving collaboration among obstetricians, internists, rheumatologists, and hematologists. Accurate diagnosis, tailored anticoagulation strategies, and continuous monitoring stand as indispensable pillars for maternal and fetal well-being. (© 2024 The Authors.)
Databáze:	MEDLINE
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