Biomarkers of chronic inflammation and cognitive decline: A prospective observational study.

Autor: Guduguntla BA; University of Michigan Medical School Ann Arbor Michigan USA., Vasbinder A; Division of Cardiology Department of Internal Medicine University of Michigan Ann Arbor Michigan USA., Anderson E; Division of Cardiology Department of Internal Medicine University of Michigan Ann Arbor Michigan USA., Azam TU; Division of Cardiology Department of Internal Medicine University of Michigan Ann Arbor Michigan USA., Blakely P; Division of Cardiology Department of Internal Medicine University of Michigan Ann Arbor Michigan USA., Webster NJ; Institute for Social Research University of Michigan Ann Arbor Michigan USA., Gonzalez R; Department of Psychology University of Michigan Ann Arbor Michigan USA., Atonucci T; Department of Psychology University of Michigan Ann Arbor Michigan USA., Heidebrink JL; Department of Neurology University of Michigan Ann Arbor Michigan USA., Giordani B; Department of Psychology University of Michigan Ann Arbor Michigan USA.; Department of Neurology University of Michigan Ann Arbor Michigan USA.; Department of Psychiatry University of Michigan Ann Arbor Michigan USA., Zahodne L; Department of Psychology University of Michigan Ann Arbor Michigan USA., Hampstead BM; Department of Psychiatry University of Michigan Ann Arbor Michigan USA.; Mental Health Service Line, Veterans Affairs Ann Arbor Healthcare System Ann Arbor Michigan USA., Ajrouch KJ; Institute for Social Research University of Michigan Ann Arbor Michigan USA.; Eastern Michigan University Ypsilanti Michigan USA., Hayek SS; Division of Cardiology Department of Internal Medicine University of Michigan Ann Arbor Michigan USA.
Jazyk: angličtina
Zdroj: Alzheimer's & dementia (Amsterdam, Netherlands) [Alzheimers Dement (Amst)] 2024 Mar 26; Vol. 16 (1), pp. e12568. Date of Electronic Publication: 2024 Mar 26 (Print Publication: 2024).
DOI: 10.1002/dad2.12568
Abstrakt: We sought to determine whether the biomarkers of chronic inflammation predict cognitive decline in a prospective observational study. We measured baseline serum soluble urokinase plasminogen activator receptor (suPAR) and high sensitivity C-reactive protein (hs-CRP) levels in 282 participants of the University of Michigan Memory and Aging Project. Cognitive function was measured using the Montreal Cognitive Assessment (MoCA) and the Clinical Dementia Rating (CDR) scale for up to five time points. SuPAR and hs-CRP levels were not significantly higher in participants with mild cognitive impairment ( n  = 97) or dementia ( n  = 59), compared to those with normal cognitive function ( n  = 126). Overall, 14% of participants experienced significant cognitive decline over the study period. The change in MoCA or CDR scores over time did not differ significantly according to baseline suPAR or hs-CRP levels. Chronic systemic inflammation, as measured by serum suPAR or hs-CRP levels, is unlikely to contribute significantly to cognitive decline.
Competing Interests: SSH is a member of the scientific advisory board of Walden Biosciences. Other authors do not have a conflict of interest. Author disclosures are available in the supporting information.
(© 2024 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)
Databáze: MEDLINE
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