Cinnamic acid, a natural plant compound, exhibits neuroprotection in a mouse model of Sandhoff disease via PPARα.

Autor: Raha S; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA., Paidi RK; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA., Dutta D; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA., Pahan K; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.; Division of Research and Development, Jesse Brown Veterans Affairs Medical Center, Chicago, IL, USA.
Jazyk: angličtina
Zdroj: NeuroImmune pharmacology and therapeutics [NeuroImmune Pharm Ther] 2024 Mar 15; Vol. 3 (1), pp. 17-32. Date of Electronic Publication: 2024 Mar 15 (Print Publication: 2024).
DOI: 10.1515/nipt-2023-0027
Abstrakt: Tay-Sachs disease (TSD) and its severe form Sandhoff disease (SD) are autosomal recessive lysosomal storage metabolic disorders, which often result into excessive GM2 ganglioside accumulation predominantly in lysosomes of nerve cells. Although patients with these diseases appear normal at birth, the progressive accumulation of undegraded GM2 gangliosides in neurons leads to early death accompanied by manifestation of motor difficulties and gradual loss of behavioral skills. Unfortunately, there is still no effective treatment available for TSD/SD. The present study highlights the importance of cinnamic acid (CA), a naturally occurring aromatic fatty acid present in a number of plants, in inhibiting the disease process in a transgenic mouse model of SD. Oral administration of CA significantly attenuated glial activation and inflammation and reduced the accumulation of GM2 gangliosides/glycoconjugates in the cerebral cortex of Sandhoff mice. Besides, oral CA also improved behavioral performance and increased the survival of Sandhoff mice. While assessing the mechanism, we found that oral administration of CA increased the level of peroxisome proliferator-activated receptor α (PPARα) in the brain of Sandhoff mice and that oral CA remained unable to reduce glycoconjugates, improve behavior and increase survival in Sandhoff mice lacking PPARα. Our results indicate a beneficial function of CA that utilizes a PPARα-dependent mechanism to halt the progression of SD and thereby increase the longevity of Sandhoff mice.
Competing Interests: Competing interests: Authors state no conflict of interest.
(© 2024 the author(s), published by De Gruyter, Berlin/Boston.)
Databáze: MEDLINE
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