The pleiotropic functions of reactive oxygen species in cancer.

Autor: Wu K; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA.; Perlmutter NYU Cancer Center, New York University Grossman School of Medicine, New York, NY, USA., El Zowalaty AE; Institute of Clinical Sciences, Department of Surgery, Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg, Sweden.; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt., Sayin VI; Institute of Clinical Sciences, Department of Surgery, Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg, Sweden. volkan.sayin@gu.se.; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden. volkan.sayin@gu.se., Papagiannakopoulos T; Department of Pathology, New York University Grossman School of Medicine, New York, NY, USA. thales.papagiannakopoulos@nyulangone.org.; Perlmutter NYU Cancer Center, New York University Grossman School of Medicine, New York, NY, USA. thales.papagiannakopoulos@nyulangone.org.
Jazyk: angličtina
Zdroj: Nature cancer [Nat Cancer] 2024 Mar; Vol. 5 (3), pp. 384-399. Date of Electronic Publication: 2024 Mar 22.
DOI: 10.1038/s43018-024-00738-9
Abstrakt: Cellular redox homeostasis is an essential, dynamic process that ensures the balance between reducing and oxidizing reactions within cells and thus has implications across all areas of biology. Changes in levels of reactive oxygen species can disrupt redox homeostasis, leading to oxidative or reductive stress that contributes to the pathogenesis of many malignancies, including cancer. From transformation and tumor initiation to metastatic dissemination, increasing reactive oxygen species in cancer cells can paradoxically promote or suppress the tumorigenic process, depending on the extent of redox stress, its spatiotemporal characteristics and the tumor microenvironment. Here we review how redox regulation influences tumorigenesis, highlighting therapeutic opportunities enabled by redox-related alterations in cancer cells.
(© 2024. Springer Nature America, Inc.)
Databáze: MEDLINE
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