Long-Term Impact of Left Bundle Branch Block on Cardiopulmonary Exercise Test Variables and Left Ventricular Systolic Function: A Two-Stage Observational Study.

Autor: Melo Santos AC; Department of Medicine, Tiradentes University, Aracaju, Brazil., de Melo EV; Department of Medicine, Federal University of Sergipe, Aracaju, Brazil., Sousa ACS; Department of Medicine, Federal University of Sergipe, Aracaju, Brazil.; Graduate Program in Health Sciences, Federal University of Sergipe, Aracaju, Brazil.; São Lucas Clinic and Hospital/Rede D'Or São Luiz, Aracaju, Brazil.; Division of Cardiology, University Hospital, Federal University of Sergipe, Aracaju, Brazil., Oliveira JLM; Department of Medicine, Federal University of Sergipe, Aracaju, Brazil.; Graduate Program in Health Sciences, Federal University of Sergipe, Aracaju, Brazil.; São Lucas Clinic and Hospital/Rede D'Or São Luiz, Aracaju, Brazil.; Division of Cardiology, University Hospital, Federal University of Sergipe, Aracaju, Brazil., Martins-Filho PR; Graduate Program in Health Sciences, Federal University of Sergipe, Aracaju, Brazil.; Investigative Pathology Laboratory, Federal University of Sergipe, Aracaju, Brazil., Noronha NCM; Department of Medicine, Tiradentes University, Aracaju, Brazil., do Nascimento CIS; Department of Medicine, Tiradentes University, Aracaju, Brazil., Campos MDSB; Department of Medicine, Tiradentes University, Aracaju, Brazil.; Graduate Program in Health Sciences, Federal University of Sergipe, Aracaju, Brazil.; São Lucas Clinic and Hospital/Rede D'Or São Luiz, Aracaju, Brazil.; Division of Cardiology, University Hospital, Federal University of Sergipe, Aracaju, Brazil.
Jazyk: angličtina
Zdroj: Cardiology [Cardiology] 2024; Vol. 149 (4), pp. 332-337. Date of Electronic Publication: 2024 Mar 26.
DOI: 10.1159/000538522
Abstrakt: Introduction: Left bundle branch block (LBBB) disrupts the electrical activation of the left ventricle, potentially impairing its systolic function, leading to LBBB-induced cardiomyopathy. This study examined cardiopulmonary exercise test (CPET) variables in patients with and without LBBB and assessed the longitudinal development of left ventricular ejection fraction (LVEF).
Method: An observational, comparative clinical study was executed in two stages at a private hospital in Brazil. The sample consisted of 27 individuals: 11 with LBBB and 16 without LBBB, all with preserved LVEF (>50%) and without confirmed ischemia. CPET variables were assessed, and after 4 years, participants had a transthoracic echocardiogram for LVEF re-evaluation. Groups were compared using the t test or the χ2 test. Multivariate analysis of covariance determined effect magnitude.
Results: Patients with LBBB demonstrated significant differences in CPET variables, particularly in predicted peak INLINEMATHCO2 slope. Despite differences in cardiopulmonary function and changes in LVEF over time between patients with and without LBBB, the effect size was considered mild to moderate.
Conclusions: LBBB patients with initially preserved LVEF displayed reduced exercise tolerance and a decrease in LVEF over time, emphasizing the need for vigilant monitoring and early intervention in these patients.
(© 2024 S. Karger AG, Basel.)
Databáze: MEDLINE
Externí odkaz: