Safety of local anesthesia in endovascular treatment of Aneurysms: A systematic review and Meta-Analysis.

Autor: Batista S; Federal University of Rio de Janeiro, Faculty of Medicine, Rio de Janeiro, Brazil., Ferreira MY; Ninth July University, Faculty of Medicine, São Paulo, Brazil. Electronic address: marcioferreiramed@gmail.com., Borges J; No affiliation., Oliveira LB; State University of Ponta Grossa, Faculty of Medicine, Paraná, Brazil., Slawka E; Federal University of Rio de Janeiro, Faculty of Medicine, Rio de Janeiro, Brazil., Bertani R; Department of Neurosurgery, University of São Paulo, São Paulo, Brazil., Besborodco RM; Rusk Rehabilitation, NYU Langone Health, NY, USA., Bocanegra-Becerra JE; Department of Medicine, Health Center of Totorabamba, Ministry of Health, Apurimac, Peru., Oberman DZ; Department of Neurosurgery, Hospital de Força Aérea do Galeão, Rio de Janeiro, Brazil., Almeida Filho JA; Department of Neurosurgery, Paulo Niemeyer State Brain Institute, Rio de Janeiro, Brazil.
Jazyk: angličtina
Zdroj: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia [J Clin Neurosci] 2024 May; Vol. 123, pp. 47-54. Date of Electronic Publication: 2024 Mar 25.
DOI: 10.1016/j.jocn.2024.03.018
Abstrakt: Background: Endovascular treatment of intracranial aneurysms (EVTIAs) is increasingly popular due to its minimally invasive nature and high success rate. While general anesthesia (GA) has been the historical preference for EVTIAs, there's growing interest in local anesthesia (LA). However, concerns persist about LA safety for EVTIAs. Therefore, we conducted a systematic review and meta-analysis to assess LA safety for EVTIAs.
Methods: Following PRISMA guidelines, we searched PubMed, Embase, and Web of Science databases. Pooled analysis with 95 % confidence intervals (CI) assessed effects, I 2 statistics gauged heterogeneity, and a random-effects model was adopted. Conversion to GA, neurological or procedure-related complications, intraoperative intracranial hemorrhagic complications (IIHC), and mortality were assessed. Subanalyses for ruptured and unruptured cases were performed.
Results: The analysis included eleven studies, 2,133 patients, and 2,369 EVTIAs under LA. Conversion to GA rate was 1 % (95 %CI: 0 to 2 %). Neurological or procedure-related complications rate was 13 % (95 % CI: 8 % to 17 %). IIHC analysis revealed a rate of 1 % (95 % CI: 1 % to 2 %). The mortality rate was 0 % (95 %CI: 0 % to 0 %). Subanalyses revealed similar rates in ruptured and unruptured subgroups, except for a slightly high rate of complications and IIHC in the ruptured subgroup.
Conclusion: Findings indicate that EVTIA under LA is safe, with low conversion and mortality rates, even for ruptured aneurysms. Complications rates, also in IIHC rates, are comparable to those reported for GA, emphasizing LA's comparable safety profile in EVTIAs. Considering these promising outcomes, the decision to opt for the LA approach emerges as meaningful and well-suited for the endovascular treatment of aneurysms. Beyond its safety, LA introduces inherent supplementary advantages, including shortened hospitalization periods, cost-effectiveness, and an expedited patient recovery process.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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