Cutaneous Angiosarcoma Subtypes: A Quantitative Systematic Review of Demographics, Treatments, and Outcomes Within Published Patient-Level Cases.
| Autor: | Kwapnoski Z; Department of Dermatology, University of California Davis, Sacramento, CA., Clarey D; Department of Dermatology, University of Nebraska Medical Center, Omaha, NE., Ma J; Department of Biostatistics, University of Nebraska Medical Center, Omaha, NE., Schmidt CM; University of Nebraska, Medical Center, Leon S. McGoogan Health Sciences Library, Omaha, NE., Wysong A; Department of Dermatology, University of Nebraska Medical Center, Omaha, NE. |
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| Jazyk: | angličtina |
| Zdroj: | Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] [Dermatol Surg] 2024 Jul 01; Vol. 50 (7), pp. 620-626. Date of Electronic Publication: 2024 Mar 26. |
| DOI: | 10.1097/DSS.0000000000004174 |
| Abstrakt: | Background: Cutaneous angiosarcoma (cAS) is a highly aggressive malignancy arising from the vascular endothelium. Given its rarity, there is insufficient data detailing patient demographics, management, and survival outcomes. Objective: To systematically compile published patient-level cases of cAS and to quantify and analyze data on demographics, management, and outcomes while determining prognostic indicators. Materials and Methods: Searches of EBSCOhost, MEDLINE, EMBASE, and the Cochrane Library generated 1,500 cases of cAS with individual level data available. PRISMA guidelines were followed. Results: Cutaneous angiosarcoma presented most often on the scalp of elderly men. Metastasis occurred in 36.3% of cases. Aggregate 5-year survival was 31.6% with the median survival of 25 months. The best 5-year survival was in the radiation-associated subtype (48.8%), whereas the worst was in the Stewart-Treves subtype (21.6%). Using multivariate analysis, gender, age group, disease subtype, treatment modality, and metastasis at presentation had significant effects on survival outcomes ( p < .05). Conclusion: The breadth of information obtained enables this study to serve as a resource that clinicians may reference when they encounter cAS. (Copyright © 2024 by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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