Hypertension and Risk of Endometrial Cancer: A Pooled Analysis in the Epidemiology of Endometrial Cancer Consortium (E2C2).

Autor:	Habeshian TS; Department of Population and Public Health Sciences, Keck School of Medicine of USC, University of Southern California, Los Angeles, California.; Department of Research and Evaluation, Division of Health Services Research and Implementation Science, Kaiser Permanente Southern California, Pasadena, California., Peeri NC; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York., De Vivo I; Department of Epidemiology, Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, Massachusetts.; Medicine, Harvard Medical School, Boston, Massachusetts., Schouten LJ; Department of Epidemiology, GROW-Research Institute for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, the Netherlands., Shu XO; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee., Cote ML; Fairbanks School of Public Health, Department of Epidemiology, Indiana University Simon Comprehensive Cancer Center, Indianapolis, Indiana., Bertrand KA; Slone Epidemiology Center, Boston University, Boston, Massachusetts., Chen Y; Population Health, New York University School of Medicine, New York, New York., Clarke MA; Division of Cancer Epidemiology and Genetics, NCI, Rockville, Maryland., Clendenen TV; Population Health, New York University School of Medicine, New York, New York., Cook LS; Epidemiology, Colorado School of Public Health, Aurora, Colorado., Costas L; Cancer Epidemiology Research Programme, Institut Català d'Oncologia, Barcelona, Spain.; Consortium for Biomedical Research in Epidemiology and Public Health - CIBERESP, Carlos III Institute of Health, Madrid, Spain., Dal Maso L; Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy., Freudenheim JL; Department of Epidemiology and Environmental Health, University at Buffalo, State University of New York, Buffalo, New York., Friedenreich CM; Department of Cancer Epidemiology and Prevention Research, Alberta Health Services, Calgary, Alberta, Canada., Gallagher G; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York., Gierach GL; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland., Goodman MT; Cancer Prevention and Control Program, Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California., Jordan SJ; School of Public Health, University of Queensland, Herston, Queensland, Australia., La Vecchia C; Department of Clinical Medicine and Community Health, University of Milan, Milan, Italy., Lacey JV; Department of Computational and Quantitative Medicine, City of Hope, Duarte, California., Levi F; Epidemiology and Health Services Research, University of Lausanne, Lausanne, Switzerland., Liao LM; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland., Lipworth L; Department of Medicine, Vanderbilt University, Nashville, Tennessee., Lu L; Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut., Matias-Guiu X; Department of Pathology, University Hospital of Bellvitge, IDIBELL, Barcelona, Spain., Moysich KB; Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, New York., Mutter GL; Pathology, Brigham and Women's Hospital, Boston, Massachusetts., Na R; Population Health, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia., Naduparambil J; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York., Negri E; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy., O'Connell K; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York., O'Mara TA; Cancer Research Program, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia., Onieva Hernández I; Faculty of Medicine, Cancer Epidemiology Research Programme and University of Barcelona, Institut Català d'Oncologia, Barcelona, Spain., Palmer JR; Slone Epidemiology Center and Department of Medicine, Boston University, Boston, Massachusetts., Parazzini F; Department of Clinical Medicine and Community Health, University of Milan, Milan, Italy., Patel AV; Population Science, American Cancer Society, Kennesaw, Georgia., Penney KL; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital/Harvard Medical School, Boston, Massachusetts., Prizment AE; Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, Minnesota., Ricceri F; Department of Clinical and Biological Sciences, University of Turin, Orbassano, Italy., Risch HA; Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut., Sacerdote C; Unit of Cancer Epidemiology, Azienda Ospedaliera Citta' della Salute e della Scienza di Torino, Turin, Italy., Sandin S; Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York., Stolzenberg-Solomon RZ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland., van den Brandt PA; Epidemiology, Maastricht University, Maastricht, the Netherlands., Webb PM; Population Health Program, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia., Wentzensen N; Division of Cancer Epidemiology and Genetics, NCI, Rockville, Maryland., Wijayabahu AT; Division of Cancer Epidemiology and Genetics, NCI, Rockville, Maryland., Wilkens LR; Department of Epidemiology, University of Hawaii Cancer Center, Honolulu, Hawaii., Xu W; Epidemiology, Fudan University School of Public Health, Shanghai, China., Yu H; Cancer Center, University of Hawaii, Honolulu, Hawaii., Zeleniuch-Jacquotte A; Population health, New York University School of Medicine, New York, New York., Zheng W; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee., Du M; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York., Setiawan VW; Department of Population and Public Health Sciences, Keck School of Medicine of USC, University of Southern California, Los Angeles, California.; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California.
Jazyk:	angličtina
Zdroj:	Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Cancer Epidemiol Biomarkers Prev] 2024 Jun 03; Vol. 33 (6), pp. 788-795.
DOI:	10.1158/1055-9965.EPI-23-1444
Abstrakt:	Background: The incidence rates of endometrial cancer are increasing, which may partly be explained by the rising prevalence of obesity, an established risk factor for endometrial cancer. Hypertension, another component of metabolic syndrome, is also increasing in prevalence, and emerging evidence suggests that it may be associated with the development of certain cancers. The role of hypertension independent of other components of metabolic syndrome in the etiology of endometrial cancer remains unclear. In this study, we evaluated hypertension as an independent risk factor for endometrial cancer and whether this association is modified by other established risk factors. Methods: We included 15,631 endometrial cancer cases and 42,239 controls matched on age, race, and study-specific factors from 29 studies in the Epidemiology of Endometrial Cancer Consortium. We used multivariable unconditional logistic regression models to estimate ORs and 95% confidence intervals (CI) to evaluate the association between hypertension and endometrial cancer and whether this association differed by study design, race/ethnicity, body mass index, diabetes status, smoking status, or reproductive factors. Results: Hypertension was associated with an increased risk of endometrial cancer (OR, 1.14; 95% CI, 1.09-1.19). There was significant heterogeneity by study design (Phet < 0.01), with a stronger magnitude of association observed among case-control versus cohort studies. Stronger associations were also noted for pre-/perimenopausal women and never users of postmenopausal hormone therapy. Conclusions: Hypertension is associated with endometrial cancer risk independently from known risk factors. Future research should focus on biologic mechanisms underlying this association. Impact: This study provides evidence that hypertension may be an independent risk factor for endometrial cancer. (©2024 The Authors; Published by the American Association for Cancer Research.)
Databáze:	MEDLINE
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