Clinical comparison of HMPV and RSV infections in hospitalised Malaysian children: A propensity score matched study.

Autor: Ng DC; Hospital Tuanku Ja'afar, Ministry of Health Malaysia, Seremban, Malaysia., Liew CH; Hospital Tuanku Ampuan Najihah, Ministry of Health Malaysia, Kuala Pilah, Malaysia., Tan KK; Department of Paediatrics, Perdana University Seremban Clinical Academic Center, Seremban, Malaysia., Awang EHB; Hospital Tuanku Ja'afar, Ministry of Health Malaysia, Seremban, Malaysia., Nazri FNBA; Hospital Tuanku Ja'afar, Ministry of Health Malaysia, Seremban, Malaysia., Maran AKT; Hospital Tuanku Ja'afar, Ministry of Health Malaysia, Seremban, Malaysia., Mohan VAAC; Hospital Tuanku Ja'afar, Ministry of Health Malaysia, Seremban, Malaysia., Ramachandran D; Hospital Tuanku Ampuan Najihah, Ministry of Health Malaysia, Kuala Pilah, Malaysia., Chok M; Hospital Tuanku Ja'afar, Ministry of Health Malaysia, Seremban, Malaysia., Teh CH; Hospital Tuanku Ja'afar, Ministry of Health Malaysia, Seremban, Malaysia., Mohamad Nor A; Hospital Tuanku Ja'afar, Ministry of Health Malaysia, Seremban, Malaysia., Baharuddin SB; Hospital Tuanku Ja'afar, Ministry of Health Malaysia, Seremban, Malaysia., Khoo EJ; Department of Paediatrics, International Medical University, Kuala Lumpur, Malaysia.; Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Jazyk: angličtina
Zdroj: The clinical respiratory journal [Clin Respir J] 2024 Mar; Vol. 18 (3), pp. e13747.
DOI: 10.1111/crj.13747
Abstrakt: Introduction: Human metapneumovirus (hMPV) and respiratory syncytial virus (RSV) are significant contributors to the burden of acute respiratory infections in children, but data on hMPV from Southeast Asia are limited despite its potential for serious disease. This study aimed to compare the clinical presentation, resource utilisation and outcomes between hMPV and RSV infections in hospitalised Malaysian children.
Methods: This retrospective, observational study included children aged ≤12 years old hospitalised with hMPV or RSV, confirmed via direct fluorescent antibody (DFA) methods, between 1 July to 30 October 2022 at Hospital Tuanku Ja'afar Seremban, Malaysia. Demographic, clinical presentation, resource utilisation and outcome data were analysed. Propensity score matching was used to balance cohorts based on key demographic and clinical characteristics.
Results: This study included 192 patients, comprising 112 with hMPV and 80 with RSV. hMPV patients were older (median age 20.5 vs. 9.4 months, p < 0.001) and had a higher incidence of comorbidities (24.1% vs. 7.5%, p = 0.003). Fever was more common in the hMPV group (97.3% vs. 73.8%, p < 0.001), but the other clinical manifestations were similar. Postmatching analysis showed higher corticosteroid use in the hMPV group (p = 0.01). No significant differences were observed in the use of other resources, PICU admissions, duration of hospitalisation or mortality rates between both groups.
Conclusion: hMPV and RSV infections in children share similar clinical manifestations and outcomes, with hMPV affecting older children and showing higher corticosteroid usage. These findings emphasise the need for equal clinical vigilance for both hMPV and RSV in paediatric respiratory infections.
(© 2024 The Authors. The Clinical Respiratory Journal published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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