Magnetic resonance imaging based finite element modelling of the proximal femur: a short-term in vivo precision study.

Autor: Majcher KB; Department of Mechanical Engineering, University of Saskatchewan, 57 Campus Drive, Saskatoon, SK, S7N 5A9, Canada., Kontulainen SA; College of Kinesiology, University of Saskatchewan, 87 Campus Drive, Saskatoon, SK, S7N 0W6, Canada. saija.k@usask.ca.; Division of Biomedical Engineering, University of Saskatchewan, 57 Campus Drive, Saskatoon, SK, S7N 5A9, Canada. saija.k@usask.ca., Leswick DA; Department of Medical Imaging, University of Saskatchewan, 103 Hospital Drive, Saskatoon, SK, S7N 0W8, Canada., Dolovich AT; Department of Mechanical Engineering, University of Saskatchewan, 57 Campus Drive, Saskatoon, SK, S7N 5A9, Canada.; Division of Biomedical Engineering, University of Saskatchewan, 57 Campus Drive, Saskatoon, SK, S7N 5A9, Canada., Johnston JD; Department of Mechanical Engineering, University of Saskatchewan, 57 Campus Drive, Saskatoon, SK, S7N 5A9, Canada. jd.johnston@usask.ca.; Division of Biomedical Engineering, University of Saskatchewan, 57 Campus Drive, Saskatoon, SK, S7N 5A9, Canada. jd.johnston@usask.ca.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Mar 25; Vol. 14 (1), pp. 7029. Date of Electronic Publication: 2024 Mar 25.
DOI: 10.1038/s41598-024-57768-7
Abstrakt: Proximal femoral fractures are a serious life-threatening injury with high morbidity and mortality. Magnetic resonance (MR) imaging has potential to non-invasively assess proximal femoral bone strength in vivo through usage of finite element (FE) modelling (a technique referred to as MR-FE). To precisely assess bone strength, knowledge of measurement error associated with different MR-FE outcomes is needed. The objective of this study was to characterize the short-term in vivo precision errors of MR-FE outcomes (e.g., stress, strain, failure loads) of the proximal femur for fall and stance loading configurations using 13 participants (5 males and 8 females; median age: 27 years, range: 21-68), each scanned 3 times. MR-FE models were generated, and mean von Mises stress and strain as well as principal stress and strain were calculated for 3 regions of interest. Similarly, we calculated the failure loads to cause 5% of contiguous elements to fail according to the von Mises yield, Brittle Coulomb-Mohr, normal principal, and Hoffman stress and strain criteria. Precision (root-mean squared coefficient of variation) of the MR-FE outcomes ranged from 3.3% to 11.8% for stress and strain-based mechanical outcomes, and 5.8% to 9.0% for failure loads. These results provide evidence that MR-FE outcomes are a promising non-invasive technique for monitoring femoral strength in vivo.
(© 2024. The Author(s).)
Databáze: MEDLINE
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