High allelic diversity in Arabidopsis NLRs is associated with distinct genomic features.
| Autor: | Sutherland CA; Department of Plant and Microbial Biology, University of California Berkeley, Berkeley, CA, 94720, USA., Prigozhin DM; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA., Monroe JG; Department of Plant Sciences, University of California Davis, Davis, CA, 95616, USA., Krasileva KV; Department of Plant and Microbial Biology, University of California Berkeley, Berkeley, CA, 94720, USA. kseniak@berkeley.edu. |
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| Jazyk: | angličtina |
| Zdroj: | EMBO reports [EMBO Rep] 2024 May; Vol. 25 (5), pp. 2306-2322. Date of Electronic Publication: 2024 Mar 25. |
| DOI: | 10.1038/s44319-024-00122-9 |
| Abstrakt: | Plants rely on Nucleotide-binding, Leucine-rich repeat Receptors (NLRs) for pathogen recognition. Highly variable NLRs (hvNLRs) show remarkable intraspecies diversity, while their low-variability paralogs (non-hvNLRs) are conserved between ecotypes. At a population level, hvNLRs provide new pathogen-recognition specificities, but the association between allelic diversity and genomic and epigenomic features has not been established. Our investigation of NLRs in Arabidopsis Col-0 has revealed that hvNLRs show higher expression, less gene body cytosine methylation, and closer proximity to transposable elements than non-hvNLRs. hvNLRs show elevated synonymous and nonsynonymous nucleotide diversity and are in chromatin states associated with an increased probability of mutation. Diversifying selection maintains variability at a subset of codons of hvNLRs, while purifying selection maintains conservation at non-hvNLRs. How these features are established and maintained, and whether they contribute to the observed diversity of hvNLRs is key to understanding the evolution of plant innate immune receptors. (© 2024. The Author(s).) |
| Databáze: | MEDLINE |
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