A rare case of cutaneous granular cell tumor with unusual Melan-A expression in a child.

Autor: Cheng NH; Drexel University College of Medicine, Philadelphia, Pennsylvania, USA., Smith D; Department of Dermatology, St. Luke's University Health Network, Bethlehem, Pennsylvania, USA., Errickson C; Department of Dermatology, St. Luke's University Health Network, Bethlehem, Pennsylvania, USA., Ashi S; Schweiger Dermatology Group, Philadelphia, Pennsylvania, USA.
Jazyk: angličtina
Zdroj: Journal of cutaneous pathology [J Cutan Pathol] 2024 Jun; Vol. 51 (6), pp. 434-438. Date of Electronic Publication: 2024 Mar 25.
DOI: 10.1111/cup.14619
Abstrakt: Granular cell tumors (GCTs) are rare, indolent neoplasms classically characterized by eosinophilic granular cytoplasm, infiltrations of polygonal cells in the collagenous stroma, and pustulo-ovoid bodies of Milian. We describe a case of a 10-year-old female presenting with a GCT of the upper arm, remarkable for positive Melan-A expression without additional melanocytic features. The differentiation between granular cells versus melanocytic neoplasms carries significant implications for clinical management, and such diagnoses should be considered carefully in the setting of unusual immunophenotypes.
(© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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