Tertiary prevention strategies for micrometastatic lymph node cervical cancer: A systematic review and a prototype of an adapted model of care.

Autor: Śniadecki M; Department of Gynaecology and Obstetrics, Medical University of Gdańsk, Gdańsk, Poland. Electronic address: marcinsniadecki@gumed.edu.pl., Guani B; Hospital of Fribourg HFR, Chemin des Pensionnats 2/6, Villars-sur-Glâne 1752, Switzerland., Jaworek P; Department of Gynaecology and Obstetrics, Medical University of Gdańsk, Gdańsk, Poland., Klasa-Mazurkiewicz D; Department of Gynaecology and Obstetrics, Medical University of Gdańsk, Gdańsk, Poland., Mahiou K; Breast, Gynaecology and Reconstructive Surgery Unit, Institute Curie, Paris, France., Mosakowska K; Department of Gynaecology and Obstetrics, Medical University of Gdańsk, Gdańsk, Poland., Buda A; Department of Gynaecology Oncology, Michele e Pietro Ferrero Hospital, Verduno, Italy., Poniewierza P; Department of Family Medicine, Lazarski University, Warsaw, Poland., Piątek O; Department of Gynaecology and Obstetrics, Medical University of Gdańsk, Gdańsk, Poland., Crestani A; Department of Gynaecological Surgery, Hospital Tenon, Paris, France., Stasiak M; Department of Gynaecology and Obstetrics, Medical University of Gdańsk, Gdańsk, Poland., Balaya V; Department of Obstetrics and Gynaecology, Félix Guyon Hospital, CHU La Réunion, La Reunion Island, France., Musielak O; Department of Surgical Oncology, Transplant and General Surgery, Medical University of Gdańsk, Gdańsk, Poland., Piłat L; Department of Gynaecology and Obstetrics, Medical University of Gdańsk, Gdańsk, Poland., Maliszewska K; Department of Gynaecology and Obstetrics, Medical University of Gdańsk, Gdańsk, Poland., Aristei C; Radiation Oncology Section, Department of Medicine and Surgery, University of Perugia and Perugia General Hospital, Sant'Andrea delle Fratte, Perugia, Italy., Guzik P; Clinical Department of Gynaecology and Obstetrics, City Hospital Rzeszów, Rzeszów, Poland., Wojtylak S; Department of Pathology, Medical University of Gdańsk, Gdańsk, Poland., Liro M; Department of Gynaecology and Obstetrics, Medical University of Gdańsk, Gdańsk, Poland., Gaillard T; Department of Surgery, Institute Curie, University Paris Cite, Paris, France., Kocian R; Department of Gynaecology, Obstetrics and Neonatology, General University Hospital and First Faculty of Medicine, Charles University, Prague, Czech Republic., Gołąbiewska A; Department of Environmental Technology, Faculty of Chemistry, University of Gdańsk, Gdańsk, Poland., Chmielewska Z; Department of Gynaecology and Obstetrics, Medical University of Gdańsk, Gdańsk, Poland., Wydra D; Department of Gynaecology and Obstetrics, Medical University of Gdańsk, Gdańsk, Poland.
Jazyk: angličtina
Zdroj: Critical reviews in oncology/hematology [Crit Rev Oncol Hematol] 2024 May; Vol. 197, pp. 104329. Date of Electronic Publication: 2024 Mar 26.
DOI: 10.1016/j.critrevonc.2024.104329
Abstrakt: Purpose: We found a need for balancing the application of clinical guidelines and tailored approaches to follow-up of cervical cancer (CC) patients in the lymph node micrometastatic (MICs) setting. This review aimed to determine the current knowledge of management of MIC-positive CC cases.
Methodology: We addressed prognostic and risk of recurrence monitoring impacts associated with MIC+ cases. The electronic databases for literature and relevant articles were analysed.
Results: Fifteen studies, (4882 patients), were included in our systematic review. While the results show that MICs significantly worsen prognosis in early CC. A tertiary prevention algorithm for low volume lymph node disease may stratify follow-up according to the burden of nodal disease and provide data that helps improve follow-up performance.
Conclusion: MICs worsen prognosis and should be managed as suggested by the algorithm. However, this algorithm must be externally validated. The clinical impact of isolated tumor cells (ITC) remains unclear.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: